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血管内皮素转换酶-1b C-338A基因多态性与冠心病相关性研究 被引量:1

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摘要 近年来对内皮素-1(ET-1)研究表明,ET-1能提高血管平滑肌的有丝分裂和增殖,在动脉硬化进程中起了重要作用。血管内皮素转换酶-1b(ECE-1b)C-338A基因多态性的位点位于ECE-1基因启动子(翻译起始点上游338bp)已经明确,且A等位基因比C等位基因有更强的转录活性^[2]。本研究旨在此基础上,探讨ECE—1b C-338A基因多态性与国人冠心病发病危险性的关系。
出处 《中华老年心脑血管病杂志》 CAS 北大核心 2008年第11期860-860,共1页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
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  • 1Funke-Kaiser H, Reichenberger F, Kopke K, et al. Differential binding of transcription factor E2F-2 to the endothelin-converring enzyme-1b promoter affects blood pressure regulation. Hum Mol Genet, 2003,12 : 423-433.
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同被引文献11

  • 1Erbel C, Sato K, Meyer FB, et al. Functional profile of activated dendritic cells in unstable atherosclerotic plaque [J]. Basic Res Cardiol, 2007, 102(2): 123-132.
  • 2Breland UM, Michelsen AE, Skjelland M, et al. Raised MCP-4 levels in symptomatic carotid atherosclerosis: an inflammatory link between platelet and monoeyte activation [J]. Cardiovase Res, 2010, 86(2): 265-273.
  • 3Deng HB, Jiang CQ, Tomlinsona B, et al. A polymorphism in transforming growth factor β1 is associated with carotid plaques and increased carotid intimamedia thickness in older Chinese men: The Guangzhou Biobank Cohort Study Cardiovascular Disease Subeohort[J]. Atherosclerosis, 2011,214(2): 391-396.
  • 4Jin Z, Luxiang C, Huadong Z, et al. C-338A polymorphism of the endothelin-converting enzyme-1 gene and the susceptibility to carotid atherosclerosis[J]. Microvas Res, 2009, 78(1): 128-131.
  • 5Zha Y, Leung KH, Lo KK, et al. TGF β1 as a susceptibility gene for high myopia: a replication study with new findings [J]. Arch Ophthalmol, 2009, 127(4):541-548.
  • 6Scacchi R, Gambina G, Broggio E, et al. C-338A polymorphism of the endothelin- converting enzyme (ECE-1) gene and the susceptibility to sporadic late-onset Alzheimer's disease and coronary artery disease[J]. Dis Markers, 2008, 24(3): 175-179.
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  • 8Jiang CQ, Lam TH, Lin JM, et al. An overview of the Guangzhou biobank cohort study-cardiovascular disease subcohort (GBCS-CVD): a platform for multidisciplinary collaboration [J]. J Hum Hypertens, 2010, 24(2): 139-150.
  • 9夏章勇,杨华,曲怀谦,崔可密,程卫东.短暂性脑缺血发作患者介入治疗术后炎性因子的动态变化及其与再狭窄的关系[J].中华神经医学杂志,2010,9(7):657-661. 被引量:14
  • 10林静,易兴阳,池丽芬,潘继豹,张顺开.血清TGF-β1和VEGF与脑梗死患者颈动脉粥样斑块易损性的相关性[J].中国神经免疫学和神经病学杂志,2010,17(4):269-272. 被引量:10

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