摘要
目的:探讨Survivin和CD105在肺癌组织中的表达与预后的关系。方法:应用免疫组化检测化疗组(35例)和非化疗组(35例)的肺癌患者中Survivin和CD105的表达水平,比较Survivin和CD105的表达与生存率的关系。结果:Survivin和CD105在肺癌组织中的阳性表达率分别为74.3%(52/70)和67.1%(47/70),两者呈正相关,χ2=0.525,P=0.000;化疗组Survivin和CD105不同表达的患者与非化疗组的中位生存时间(MST)差异有统计学意义,χ2=57.978,P=0.000;化疗组中Survivin和CD105表达阴性者生存时间明显长于阳性表达者。结论:Survivin与CD105在肺癌组织中表达是判断化疗疗效和预后的重要指标。
OBJECTIVE：To study the relationship between the expressions of Survivin and CD105 and the prognosis in lung cancer. METHODS： The expressions of Survivin and CD105 were detected by immunohischemistry in 35 patients with lung cancer of chemotherapy group and 35 patients with lung cancer of non-chemotherapy group. The relationship between their expressions and Survival rates was analysed. RESULTS： The positive rates of Survivin and CD105 were 74.3%（52/70） and 67.1%（47/70）, respectively, The Survivin and CD105 were positive correlated in lung cancer tissues, χ^2=0.525, P=0.000, and there was a significant difference in the mid-survival time between the expressions of Survivin and CD105 in the two groups, χ^2=57.978, P=0.000. The Survival time of negative expressions of Survivin and CD105 in the chemotherapy group was the longest one. CONCLUSION： The expressions of Survivin and CD105 in lung cancer might be important markers in evaluating the effect of chemotherapy and predicting the prognosis in lung cancer.
出处
《中华肿瘤防治杂志》
CAS
2008年第16期1244-1246,共3页
Chinese Journal of Cancer Prevention and Treatment
基金
河北省科技厅指导性课题(20042761356)
