摘要
随着人类对椎间盘退行性变疾病更深入的认识和分子生物学技术的研究进展及其在临床上的应用,在椎间盘退行性变时,早期进行生物学的干预,对延缓椎间盘退行性变甚至逆转疾病进程产生了可能。椎间盘退行性变疾病的基因治疗研究涉及到动物模型的选取、基因载体的选择、目的基因的应用等。构建类似人体的动物模型、选择合适的基因载体和应用理想的目的基因是疾病基因治疗的关键。基因治疗必须在证实其有效性并确保患者的安全的基础上应用于临床,故目前还有许多问题有待于解决。
With deeper understanding for intervertebral disc degeneration, the development and clinical application of protocols in molecular biology, biological intervention in initial stage of intervertebral disc degeneration can retard even reverse the degeneration process. Gene therapy of intervertebral disc degeneration refers to the selection of animal models and gene carriers, application of target genes, etc. It is the key for gene therapy to build human-like animal model, select proper gene carrier and apply ideal target genes. Prior to clinical application, the safety and efficacy of gene therapy should be proved, thus many problems deserve further study.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第42期8348-8351,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
