期刊文献+

TGF-β调节的自噬与肾纤维化 被引量:10

暂未订购
导出
摘要 慢性肾脏疾病是严重威胁人类健康的常见疾病,2012年一项调查发现中国慢性肾病发病率达10.8%[1],成为继心脑血管病、肿瘤、糖尿病之后又一严重威胁人类健康的疾病,但目前还无有效治疗手段。肾纤维化是多种慢性肾脏疾病的主要病理改变,是终末期肾脏病的共同结局,其病理特点包括细胞外基质增多、肾小管扩张或萎缩、细胞凋亡等。因此,寻找肾纤维化新的治疗靶点,减缓和逆转慢性肾脏疾病进程,
出处 《中国中西医结合肾病杂志》 2016年第4期371-373,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 国家自然基金面上项目(No.81370812) 国家重点基础研究发展计划资助973项目(No.2012CB517602) 黑龙江省大学生创新创业训练计划项目(No.201310226036)
  • 相关文献

参考文献18

  • 1Zhang L, Wang F, Wang L, et al. Prevalence of chronic kidney disease in China: a cross - section survey. Lancet, 2012,379 (9818) :815 -822.
  • 2Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Ce11,2008,132( 1 ) :27 -42.
  • 3Mizushima N, Levine B, Cuervo AM, et al. Autophagy fights dis- ease through cellular self - digestion. Nature, 2008,451 ( 9 ) : 1069 - 1075.
  • 4Ravikumar B, Sarkar S, Davies JE, et al. Regulation of mammali-an autophagy in physiology and pathophysiology. Physiol Rev, 2010,90( 11 ) : 1383 - 1435.
  • 5Uranova N, Bonartsev P, Brusov O, et al. The uhrastructure of lymphocytes in schizophrenia. World J Biol Psychiatry, 2007,8 (1) :30 -37.
  • 6Ding Y, Kim S, Lee SY, et al. Autophagy regulates TGF - β ex- pression and suppresses kidney fibrosis induced by unilateral u- reteral obstruction. J Am Soc Nephrol, 2014,25 ( 12 ) : 2835 - 2846.
  • 7Jiang M, Wei Q, Dong G, et al. Autophagy in proximal tubules protects against acute kidney injury. Kidney Int, 2012,82 (11 ) : 1271 - 1283.
  • 8Xu Y, Yang S, Huang J, et al. TGF - 131 induces autopathy and promotes apoptosis in renal tubular epithelial cells. Int J Mol Med,2012,29(3) :781 -790.
  • 9Koesters R, Kaissling B, Lehir M, et al. Tubular overexpression of transforming growth factor - betal induces autophagy and fibro- sis but not mesenchymal transition of renal epithelial cells. Am J Pathol,2010,177 (3) :632 - 643.
  • 10Kim WY, Nam SA, Song HC, et al. The The role of autophagy in unilateral ureteral obstruction rat model. Nephrology (Carlton), 2012,17( 1 ) :148 - 159.

同被引文献89

引证文献10

二级引证文献83

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部