摘要
目的研究炒炭对蒙药阿给制剂中抗出血活性成分——无机元素的影响,并初步探讨阿给炭药止血作用强于生药的原因。方法采用HNO3-HClO4消解样品,电感耦合等离子体发射光谱法(ICP-AES)测定其中钾、钙、镁、锌、铁、锰、铜、铝8种无机元素的含量,并计算各元素的溶出率。结果阿给炒炭后,各无机元素的含量均升高,其中钙、镁、锌3种元素含量分别上升至生药的1.23倍、1.25倍及4.32倍;而各元素的溶出率均明显降低,其中锰的溶出率差异最大,炭药仅为生药的11.47%。结论阿给中与止血作用有关的无机元素含量丰富,且炮制后含量增加,这与其药理作用一致。但炒炭后各元素的溶出率较低,建议直接以炭的形式用药。
Objective To study the effects of drug-processing on inorganic elements which are important active ingredients in Agi （Artemisia frigida Willd.） and to understand why processed products more effective against hemorrhage than raw materials. Methods Different Agi samples including the raw herb, the processed drug and their extractions were digested with HNO3-HClO4. The contents and extraction rates of inorganic elements （K, Ca, Mg, Zn, Fe, Mn, Cu, and Al） were determined by ICP-AES. Results Agi was found to be rich in inorganic elements that are essential to hemostatic effects. The contents of all analyzed elements were increased after drug-processing. Specifically, contents of Ca, Mg and Zn were increased by 123%, 125% and 432% as compared with raw herbs. In contrast, the inorganic elements extraction rates declined significantly. Conclusion The higher contents of inorganic elements, especially Ca, may be helpful for enhanced hemostatic activity, which appeared consistent with their pharmacological effects. Since the extraction rates of all elements became lowered after processing, non-extracted products may be preferable for use.
出处
《中国药物与临床》
CAS
2008年第11期852-854,共3页
Chinese Remedies & Clinics
基金
国家自然科学基金资助项目(30672773)
