摘要
目的:通过观察比较3种方案治疗慢性重型肝炎的临床疗效,为规范化中医治疗方案的制定提供参考。方法:采用多中心、随机、平行对照临床研究方法,将150例慢性重型肝炎患者分为对照组、中医辨证治疗组及中医综合方案治疗组,均给予常规护理及西医内科治疗,疗程为60天,观察治疗前后各组患者的症状积分、肝功能指标,并发症发生率、医疗费用及不良反应。结果:中医综合治疗方案能显著改善患者症状、促进肝功能恢复、减少并发症的发生率,将慢性重型肝炎的整体临床有效率提高至78%,优于对照组与中医辨证治疗组(P<0.05或P<0.01);中医综合方案组的医疗费用仅为对照组的70%,人均减少医疗费用达1.3万元,与对照组比较差异有显著性意义(P<0.01);3组均未见有明显不良反应。结论:中医综合治疗方案能更全面地发挥中医药治疗慢性重型肝炎的作用,具有提高临床疗效、减少医疗费用、安全性高等优势,值得临床推广应用。
Objective： To Compare the clinical curative effect of 3 kinds of therapeutic regimen on chronic severe hepatitis, provided the reference for the standardized TCM therapeutic regimen formulation. Methods ： A multi - centers, random, and the parallel comparison clinical trial were conducted. A total of 150 chronic severe hepatitis patients were enrolled and divided into the control group, the TCM differentiation of symptoms and signs group, and the TCM combined treatment therapeutic regimen group. Administration to conventional nursing and the Western medicine treatment, the course of treatment was 60 days. The patient＇s symptom integral, the liver functional parameter, the complication formation rate, the medical expense and adverse effect of each group were observatcd. Results： The TCM combined therapeutic regimen could obviously improved the patient＇s symptom, promated liver function recovery, reduced complication formation rate, and enhanced chronic severe hepatitis whole clinical effectiveness to 78%, and surpassed the control group and the TCM differentiation of symptoms and signs treatment group （ P 〈0. 05 or P 〈0. 01 ） ; The TCM combined therapeutic regimen group＇s medical expense only was 70% of the control group, the average person reduction medical expense amounted to 13, 000 Yuan （RMB）, was statistics difference with the control group comparison （ P 〈 0. 05 ） ; 3 groups had not adverse effect obviously. Conclusion ： The TCM combined treatment therapeutic regimen is able to develope the curative effects of TCM to chronic severe hepatitis fully, such as enhance the clinical curative effect, reduce medical expense, has higher the secure, and so on.
出处
《中西医结合肝病杂志》
CAS
2008年第5期260-262,276,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
广西科学研究与技术开发计划项目(No.桂科攻0592007-3D
桂科攻0816004-42)
关键词
重型肝炎
慢性
规范化
中医药
临床疗效
chronic severe hepatitis
standardization
traditional Chinese medicine （TCM）
clinical curative effect
