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药物基因组学在类风湿关节炎治疗中的研究进展 被引量：2

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摘要 抗风湿病药物（DMARDs）在类风湿关节炎（rheumatoid arthritis，RA）中的治疗效果存在明显的个体差异且难以预测，这与不同个体药物代谢相关基因的差异有密切关系。药物基因组学的深入研究对于提高药物疗效和减轻药物副作用具有重要意义，可以提供个体代谢特征方面的信息，为DMARDs的个体化合理应用提供帮助。有关药物代谢酶基因多态性与药物疗效／不良反应的关联性的研究日益受到人们的关注，现就近年来DMARDs治疗RA在此方面的研究进展作一综述。
作者 邹原方 叶志中
机构地区 中山大学附属东华医院肾内风湿科 广东医学院深圳风湿病研究所
出处 《中华风湿病学杂志》 CAS CSCD 2008年第11期777-780,共4页 Chinese Journal of Rheumatology
基金 深圳市医学重点学科建设基金资助项目
关键词 药物基因组学 类风湿关节炎 治疗效果 代谢酶基因多态性 DMARDS 个体差异 抗风湿病药物 代谢相关基因
分类号 R686 [医药卫生—骨科学]
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参考文献30

  • 1Wessels JA, de Vries-Bonwstro JK, Heijmans BT, et al. Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes. Arithritis Rheum, 2006, 54: 1087- 1095.
  • 2Ranganathan P, Eisen S, Yokoyama WM, et al. Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis? Ann Rheum Dis, 2003, 62: 4-9.
  • 3刘德敏,范新萍,于德民.亚甲基四氢叶酸还原酶677C→T及1298A→C基因多态性与糖尿病心血管病变的相关性[J].中华糖尿病杂志（1006-6187）,2005,13(3):219-222. 被引量：3
  • 4Haagsma C J, Blom HI, Van Riel PL, et al. Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis. Ann Rheum Dis, 1999, 58: 79-84.
  • 5Van Ede AE, Laan RF, Blom H J, et al. The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients. Arthritis Rheum, 2001, 44: 2525-2530.
  • 6Urano W, Taniguchi A, Yamanaka H, et al. Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses, Pharmacogenetics, 2002, 12:183-190.
  • 7Weisman MH, Furst DE, Park GS, et al. Risk genotypes in folate-dependent enzymes and their association with methotrexate- related side effects in rheumatoid arthritis. Arthritis Rheum, 2006, 54: 607-612.
  • 8Kumagai K, Hiyama K, Oyama T, et al. Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis. Int J Molecular Med, 2003, 11: 593-600.
  • 9Mitomo H, Kato R, Ito A, et al. A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport. Biochemical J, 2003, 373: 767-774.
  • 10Rains CP, Noble S, Faulds D. Sulfasalazine: a review of its pharmacological properties and therapeutic efficacy in the treatment of rheumatoid arthritis. Drugs, 1995, 50: 137-156.

二级参考文献6

  • 1Ozkan Y,Ozkan E,Simsek B. Plasma total homocysteine and cysteine levels as cardiovascular risk factors in coronary heart disease.Int J Cardiol,2002,82:269-277.
  • 2Goyette P, Pai A, Milos R, et al. Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mammalian Genome,1998,9:652-656.
  • 3Blom HJ. Mutated 5,10-methylenetetrahydrofolate reductase and moderate hyperhomocysteinaemia. Eur J Pediatr,1998,157(suppl2):S131-S134.
  • 4Van der Put NM, Gabreels F, Stevens EM, et al. A second common mutation in the Methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet,1998,62:1044-1051.
  • 5Weisberg I, Tran P,Christensen B, et al. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity.Mol Genet Metab,1998,64:169-172.
  • 6Jakubowski H. Metabolism of homocysteine thiolactone in human cell cultures: possible mechasmism for pathological consequences of elevated homocysteine levels. J Biol Chem,1997,72:1935-1942.

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中华风湿病学杂志
2008年 第11期

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