亚甲基四氢叶酸还原酶基因多态性与甲氨蝶呤治疗类风湿关节炎反应关联性研究进展被引量：1

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摘要类风湿关节炎（rheumatoid arthritis，RA）是一种累及周围关节为主的多系统性炎症性的自身免疫病，我国的患病率为0．32％～0．36％．是造成我国人群丧失劳动力和致残的主要病因之一。甲氨蝶呤（methotrexate，MTX）是RA治疗中应用最广泛的改变病情抗风湿药（disease modifying antirheurnatic drug，DMARD），多项研究已证实其可降低RA活动度，延缓、稳定骨质侵蚀的进展，确定了在RA治疗中的中心地位，即使是新的生物制剂治疗的到来．MTX仍以它的低价、广泛使用和联合用药而发挥着中心作用。

作者周小妹徐建华徐胜前

机构地区安徽医科大学第一附属医院风湿免疫科

出处《中华风湿病学杂志》 CAS CSCD 2007年第8期496-499,共4页 Chinese Journal of Rheumatology

基金安徽省自然科学基金(070413098)

关键词甲氨蝶呤治疗类风湿关节炎亚甲基四氢叶酸酶基因多态性反应还原自身免疫病抗风湿药

分类号 R593.22 [医药卫生—内科学]

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参考文献23

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