摘要
目的了解无器质性心脏病频发室性早搏（室早）患者合并抑郁的发生率及相关危险因素。方法2005年10月至2007年10月在湖北、北京、广西、新疆、浙江5省市医院住院或门诊就诊，经筛查的无器质性心脏病频发室早患者1220名，填写Zung-SDS抑郁自评量表来评价患者是否合并抑郁；同时收集患者性别、年龄、文化程度、年收入、民族、社会支持、居住地、病程、24h室早次数、24h室早所占总心率的百分比、总胆固醇等11项指标，分别进行单因素和Logistic回归分析。结果1144例患者完成测评（488例男性，656例女性），其中309名（27．01％）合并抑郁症，单因素分析显示中老年、低收入、教育程度低、少数民族、24h室早所占总心率的百分数较多、病程长、社会支持差、农村居住地等的患者易发生抑郁（P〈0．05）。通过Logistic多变量逐步回归分析法显示：教育程度低（P=0．002）、农村居住地（P〈0．001）、中老年（P〈0．001）和24h室早次数较多（P=0．005）是抑郁的独立危险因素。结论在我国频发室早患者合并抑郁症并不少见，其中教育程度低、农村居住地、中老年和24h室早次数较多是独立危险因素，室早与抑郁间的关系需进一步研究。
Objective The aim of this study is to study depression and potential risk factors in Chinese persons with premature ventricular contractions （PVCs）without structural heart diseases. Methods Zung self-rating depression scale （ZSDS）was used to scan depressive symptoms. Correlation between depression and soeiodemographie,medical factors were analyzed by logistic regression. Results Of 1144 patients with PVCs [ 488 males,656 females, age （45 ± 17 ） years, disease duration 1 month - 21 years）, a total of 309 （ 27.01% ） patients were categorized as having depression. Percentage of depression in females was higher than that in males （28. 20% vs. 25.41% ,x^2 = 1.106, P = 0. 313 ）. Depression increased with age, income, education level, race, the percentage of PVCs of 24 h beats, disease duration, society support, settlement type. Multivariate logistic regression indicated that four variables-education level, settlement type, age and PVC count/24 h were significantly and independently related with depression（ P 〈 0. 05 ）. Conclusions In this Chinese population, depression in subjects with PVCs are frequent. The education level,the village settlement type, age and PVC count/24 h are independent risk factors for depression. Further research on the relationship between PVCs and depression in China is necessary.
出处
《中华心律失常学杂志》
2008年第5期364-367,共4页
Chinese Journal of Cardiac Arrhythmias
基金
国家自然科学基金项目（30700312）,湖北省“十一五”重大科技攻关项目（2006A301A04）,湖北省自然科学基金创新群体项目（2007ABC011）,湖北省心血管病学临床研究中心组建项目（2007AA301849）
致谢 在课题研究过程中得到以下专家和医师的帮助,在此一并感谢：湖北（刘丽、陈娟、黄茜、刘育、李海涛、于胜波、杨洋、张艳、杨勇、田立群、万为国、方志成、川桃、陈晓云、卓朝贵、苏锦锋）,浙江（田莉莉、何杰、刘浩、杨军）,北京（黄觊、曹丽娅、余英、段小春）,新疆（崔刚、李东煜、苟春萍、叶勇、李静波、孙娟、骆海舭）,广西（胡一文、黄东芬、徐胜、余小祥）
关键词
室性早搏
抑郁
危险因素
Premature ventricular contractions
Depression
Risk factor
