摘要
目的:探讨肝癌术前区域动脉灌注化疗对癌复发和预后的影响。方法:术前7d区域动脉灌注化疗的21例为观察组,术前7d根据癌灶位置,经股动脉插管进入肝总动脉、胃十二指肠,灌注抗癌药物5-FU750mg/m2,羟基喜树碱(HPT)20mg、顺铂80mg,检测肿瘤细胞凋亡及随访观察癌复发和生存时间,术前未行区域动脉灌注化疗的20例为对照组。结果:术前动脉化疗组与未化疗组肿瘤细胞凋亡数分别为(50.71,3.87)和(29.13,3.69)个/高倍视野,观察组1、3、5年复发率为9.1%(2/21)、23.8%(5/21)、38.1%(8/21);生存率为100%(21/21)、95.3%(20/21)、71.4(15/21)。对照组1、3、5年复发率15%(3/20)、35%(7/20)、55%(11/20);生存率为95%(19/20)、75%(15/20)、35%(7/20)。两组比较,差异均具有显著性。结论:术前区域动脉灌注化疗对肝癌细胞有明显促凋亡作用,是预防癌复发和改善预后的有效手段。
Objective： To evaluate the effect of recurrence and prognosis of hepatic carcinoma treated by presurgical TAI. Methods：7 days before surgery, 21 cases as treatment group were received TAI with seldinger technique, through the pipe, which inserted into the arteries supplying nutrition to tumor, 5-Fu, HPT and etc medicament were infused into. The death of tumor cell and recurrence and prognosis of carcinoma were analyzed. The other 20 cases, treated by hepatic resection directly. Results： 5-year survival rate of treatment group was 71.4%, while that of the other group was 35%.There was a statistically difference（P〈0.01）. Conclusion： Presurgical TAI has obvious effect in prevention of hepatic cancer recurrence.
出处
《中国医药导报》
CAS
2008年第31期29-30,共2页
China Medical Herald
关键词
肝癌
区域动脉化疗
凋亡
肿瘤复发
Hepatic carcinoma
Transcatheter arterial infusion chemotherapy
Apoptosis
Carcinoma recurrence
