伴轻度认知损害的青中年阻塞性睡眠呼吸暂停综合征患者认知损伤特点被引量：9

The features of mild cognitive impairment in young and middle-aged patients with obstructive sleep apnea syndrome

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摘要目的:通过对青中年阻塞性睡眠呼吸暂停综合征(OSAS)患者认知功能的筛查,探讨伴轻度认知损害(MCI)的OSAS患者临床记忆障碍的特点。方法:对2005年10月至2006年10月北京大学第三医院神经内科睡眠门诊就诊的主诉失眠入选的289例青中年患者行多导睡眠监测仪检查和神经心理量表检查。结果:(1)本课题观察患者年龄18～64岁,其中确诊MCI占10.7%;(2)OSAS组MCI发生率明显高于非OSAS组;(3)单因素分析结果显示,文化程度、吸烟史、饮酒史、腔隙性脑梗死、短暂性脑缺血发作、OSAS史与MCI发生可能有关;(4)OSAS合并MCI以及MCI患者指向记忆、联想学习、图像自由记忆、无意义图形再认以及人像特点回忆5项分数与非MCI患者的5项分数相比较低,差异有显著性(P<0.01);非OSAS非MCI患者记忆5项分数较OSAS患者高,差异有显著性(P<0.01);OSAS合并MCI患者与非OSA并MCI患者记忆5项分数比较差异无统计学意义(P>0.05)。结论:青中年失眠人群中MCI的发生率为10.7%,而且男性患者居多,性别存在差异。其中OSAS患者MCI发生率明显高于非OSAS患者。OSAS合并MCI患者存在显著的记忆功能的损害。 Objective To explore the clinical features of memory impairment in young and middle-aged patients with obstructive sleep apnea syndrome （OSAS） with cognitive impairment （MCI） via screening their cognitive function. Methods Polysomnography （PSG） and neuropsychological assessment were performed in 289 patients who had visited our sleep disorder clinic for the major symptom of insomnia from October 2005 to October 2006. Results （ 1 ） 10.7% of all the patients ages 18 to 64 were clinically confirmed as MCI. （2） The incidence of MCI was obviously higher in patients with OSAS than in those without OSAS. （3） One-factor analysis revealed that educational level, history of smoking or alcohol intake, lacunar cerebral infarction, TIA, and OSAS were associated with the genesis of MCI. （4） As compared with those without MCI, the scores of orientation memory, association learning, free image memory, nonsense graph recognition, and portrait character association recall were significantly lower in patients with MCI （P 〈 0.01 for all comparisons） and these scores were significantly higher in patients who had neither OSAS nor MCI than in those with OSAS （P 〈 0.01 ）. The five scores did not differ significantly between patients with MCI with OSAS and those with MCI alone （P〉 0.05 for all comparisons）. Conclusions The incidence of MCI is 10.7% in young and middle-aged patients with insomnia,mostly being male, revealing a statistical difference in gender. The occurrence of MCI is higher in patients with OSAS than in those without OSAS. The patients with OSAS with MCI have remarkable memory impairment.

作者高金颖沈扬樊东升古雅兰

机构地区航天中心医院神经内科北京大学第三医院神经内科北京大学第三医院耳鼻喉科

出处《实用医学杂志》 CAS 2008年第20期3494-3496,共3页 The Journal of Practical Medicine

关键词睡眠呼吸暂停阻塞性认知障碍青少年中年人 Sleep apnea, obstructive Cognition disorders Adolescent Middle aged

分类号 R56 [医药卫生—呼吸系统] R749.2 [医药卫生—神经病学与精神病学]

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1Peterson R C, Stevens J C, Ganguli M, et al. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology [J]. Neurology, 2001,56 (9) : 1133-1142.
2Schrder J, Kratz B, Pantel J, et al. Prevalence of mild cognitive impairment in an elderly community sample [J]. J Neural Transm Suppl, 1998,54 : 51-59.
3Ritchie K, Artero S, Touchon J, Classification criteria for mild cognitive impairment: a population-based validation study [J]. Neurology, 2001,56 ( 1 ) :37-42.
4Graham J E, Rockwood K, Beattie B L, et al. Prevalence and severity of cognitive impairment with and without dementia in an elderly population [J]. Lancet, 1997, 349(9068) : 1793-1796.
5邱昌建,唐牟尼,张伟,韩海英,戴静,卢江,吴赛,王双红,陈建民,郭林晋,丁玉琼,李胜先,刘协和.成都地区55岁及以上人群轻微认知功能损害患病率调查[J].中华流行病学杂志,2003,24(12):1104-1107. 被引量：38
6孟琛,汤哲.社区老年人认知功能变化及其预后的五年前瞻性研究[J].中华神经科杂志,2000,33(3):138-140. 被引量：63
7Kivipeho M, Helkala E L, Hanninen T, et al. Mildlife vascular risk factors and late-life mild cognitive impairment :A population-based study [J]. Neurology,2001,56(12) : 1683-1689.
8DeCarli C, Miller B L, Swan G E, et al. Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study [J]. Arch Neurlo, 2001,58 (4) : 643-647.
9Crenshaw M C, EdingerJ D. Slow-wave sleep and waking cognitive performance among older adults with and without insomnia complaints [ J ]. Physiol Behave, 1999,66 (3) : 485-492.