摘要
长期的锰暴露,可以引起锥体外系的神经损伤,出现类帕金森病的临床症状。虽然锰的神经毒性作用机制至今还不清楚,但是已有的研究表明其很可能与机体内的氧化应激状态有关。本文将从锰诱导的氧化应激对线粒体的损伤、对多巴胺能神经元及对体内钙、铁离子代谢影响的研究进展作一综述。
Long term exposure to manganese may induce extracorticospinal tract damage in nervous system causing Parkinson-like disease. Though the mechanism of the manganese-induced neurotoxicity is not clear, studies show that it might be associated with the oxidative stress status in vivo. This article is a review on several up-to-date researches concerning manganese-induced mitochondria damage, impacts on dopaminergic neurons and effects in Ca^2＋ , Fe^2＋ ion metabolism.
出处
《首都医科大学学报》
CAS
2008年第5期664-667,共4页
Journal of Capital Medical University
基金
北京市教育委员会科技发展计划面上项目(KM200510025005)
北京市优秀人才培养资助项目(20041D0501820)~~
关键词
锰
线粒体损伤
神经毒性
氧化应激
manganese
mitochondria damage
neurotoxicity
oxidative stress
