摘要
Pain associated with cancer that metastasizes to bone is often severe and debilitating.A better understanding of the neural mechanisms that mediate cancer pain is needed for the development of more effective treatments.In this study,we used an established model of cancer pain to characterize changes in response properties of dorsal horn neurons.Fibrosarcoma cells were implanted into and around the calcaneus bone in mice and extracellular electrophysiological recordings were made from wide dynamic range(WDR) and high threshold(HT) dorsal horn neurons.Responses of WDR and HT neurons evoked by mechanical,heat,and cold stimuli applied to the plantar surface of the hind paw were compared between tumor bearing mice and control mice.Mice exhibited hyperalgesia to mechanical and heat stimuli applied to their tumor-bearing hind paw.WDR neurons in tumor-bearing mice exhibited an increase in spontaneous activity,and enhanced responses to mechanical,heat,and cold stimuli as compared to controls.Our findings show that sensitization of WDR neurons,but not HT neurons,contributes to tumor-evoked hyperalgesia.
Pain associated with cancer that metastasizes to bone is often severe and debilitating. A better understanding of the neural mechanisms that mediate cancer pain is needed for the development of more effective treatments. In this study, we used an established model of cancer pain to characterize changes in response properties of dorsal horn neurons. Fibrosarcoma cells were implanted into and around the calcaneus bone in mice and extracellular electrophysiological recordings were made from wide dynamic range （WDR） and high threshold （HT） dorsal horn neurons. Responses of WDR and HT neurons evoked by mechanical, heat, and cold stimuli applied to the plantar surface of the hind paw were compared between tumor bearing mice and control mice. Mice exhibited hyperalgesia to mechanical and heat stimuli applied to their tumor-bearing hind paw. WDR neurons in tumor-bearing mice exhibited an increase in spontaneous activity, and enhanced responses to mechanical, heat, and cold stimuli as compared to controls. Our findings show that sensitization of WDR neurons, but not HT neurons, contributes to tumor-evoked hyperalgesia.
出处
《生理学报》
CAS
CSCD
北大核心
2008年第5期635-644,共10页
Acta Physiologica Sinica
基金
grants from the University of Minnesota Graduate School(DTH)and the National Institutes of Health
DA18231(DTH),DA11471and CA91007(DAS)
关键词
反应特征
感觉神经元
临床分析
癌症
cancer pain
dorsal horn
electrophysiology
hyperalgesia
sensitization
