摘要
干扰素-α是治疗慢性病毒性肝炎的主要药物之一,可通过影响肝细胞Jak-STAT信号通路,促进2′-5′-OAS、PKR和MxA等蛋白的生成发挥抗肝炎病毒作用。干扰素-α还可通过影响MAPK通路、IRS-1/PI3K-p70S6激酶通路等信号转导通路发挥作用。为延长其半衰期、增强疗效,目前已开发出多种长效干扰素,如聚乙二醇干扰素、人血清白蛋白融合干扰素、干扰素脂质体等,并有逐渐取代普通干扰素的趋势。开发出长效、高效的干扰素也越来越成为干扰素及病毒性肝炎治疗的重要发展方向。
Interferon-alpha is one of the most important drugs against hepatitis virus, and it ean inhibit the replication of virus by inducing the expression of 2′-5′-OAS, PKR, MxA through Jak- STAT pathway in hepatocytes. The effects are also concerned with other signal pathways, such as MAPK, IRS-1/PI3K-p70S6 kiaase pathways and so on. In order to prolong the half life of interferon-alpha and enhance its effectiveness, many other longlasting interferons are developed, such as pegylated interferon,recombinant human serum albumin-interferon, and liposome interferon,which maybe take the place of interferon-alpha. The research and development of more long-acting and efficient interferons are becoming a more and more important way to the antivirus treatment of hepatitis.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第10期1276-1279,共4页
Chinese Pharmacological Bulletin
基金
安徽省2006年度科技攻关资助项目(No06013063A)
关键词
干扰素-Α
长效干扰素
乙型肝炎
丙型肝炎
信号转导
interferon-alpha
long-acting interferon
hepatitis B virus
hepatitis C virus
signal transduction
