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生育三烯酚抗肿瘤作用研究进展 被引量：9

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作者 刘慧坤 孙文广 陈炳卿
机构地区 哈尔滨医科大学公共卫生学院
出处 《毒理学杂志》 CAS CSCD 北大核心 2008年第5期392-394,共3页 Journal of Toxicology
基金 国家自然科学基金资助项目(30471444)
关键词 生育三烯酚 抗肿瘤 细胞凋亡
分类号 Q566 [生物学—生物化学] R737.1 [医药卫生—肿瘤]
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参考文献17

  • 1Guthrie N, Gapor A, Chambers AF, et al. Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and - positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in comblnalion. J Nutr, 1997, 127:544-548.
  • 2McIntyre SM, Briski K, Gapor A, et al. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. Proc Soc Exp Bio Med, 2000, 224-:292-301.
  • 3Sakai M, Okabe M, Tachibana H, et al. Apoptosis induction by r-tocotrienol in human hepatoma Hep3B cells. J Nutr Biochem, 2006, 17:672-676.
  • 4Wada S, Satomi Y, Murakoshi M, et al. Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Lett, 2005, 229 : 181-191.
  • 5PAker RA, Pearce BC, Clark RW, et al. Tocotrienols regulate cholesterol production in mammalian cells by posttranscriptional suppression of 3-hydroxy-3-methylglutarylcoenzyme A reduetase. J Biol Chem, 1993, 268: 11230-11238.
  • 6Yu W, Simmons-Menchaca M, Gapor A, et al. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr Cancer, 1999, 33:26-32.
  • 7Srivastava JK, Gupta S. Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells. Biochem Biophys Res Commun, 2006, 346 : 447-453.
  • 8Takahashi K, Loo G. Disruption of mitochondria during tocotrienol-indueed apoptosis in MDA-MB-231 human breast cancer cells. Biochem Pharmacol, 2004 ~ 67:315-324.
  • 9Sylvester PW, Shah S J, Samant GV. Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of γ-tocotrienol in neoplastic mammary epithelial cells. J Plant Physio, 2005, 162:803-810.
  • 10Shun MC, Yu W, Gapor A, et al. Pro-apoptotic mechanisms of action of a novel vitamin E analog (α-TEA) and a naturally occurring from of vitamin E (δ-Tocotrienol) in MDA-MB-435 human breast cancer cells. Nutr Cancer, 2004, 48:95-105.

二级参考文献20

  • 1Mo H, Elson CE. Studies of the isoprenoid-mediated inhibition of mevaionate synthesis applied to cancer chemotherapy and ehemoprevention. Exp Biol Med ( Maywood ), 2004,229: 567-585.
  • 2Naito Y, Shimozawa M, Kuroda M, et al. Tocotrienols reduce 25- hydroxycholesterol induced monocyte-endotheliai cell interaction by inhibiting the surface expression of adhesion moleeuhs. Atherosclerosis,2005,180:19-25.
  • 3Takahashi K, Loo G. Disruption of mitochondria during tocotrienol-indueed apoptosis in MDA-MB-231 human breast cancer cells. Biochem Pharmaeol,2004,67 : 315-324.
  • 4Agarwai MK, Agarwai ML, Athar M, et al. Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. Cell Cycle, 2004,3 : 205-211.
  • 5Sayori W, Yoshiko S, Michiaki M, et al. Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Letters,2005,229:1-11.
  • 6Willett WC. Balancing life-style and genomics research for disease prevention. Science, 2002,296:695-698.
  • 7Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention: a review of the epidemiologicai evidence. Nutr Cancer, 1992,18 : 1-29.
  • 8Sen CK, Khanna S, Roy S. Toeotrienols: Vitamin E beyond tocopherols. Life Sciences,2006,78 : 2088-2098.
  • 9Reed JC. Double identity for proteins of Bcl-2 family. Nature,1997,387 : 773-776.
  • 10Tsujimoto Y, Shimizu S. Bcl-2 family: life-or-death switch.FEBS Lett,2000,466:6-10.

共引文献5

同被引文献73

引证文献9

二级引证文献175

毒理学杂志
2008年 第5期

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