摘要
众多的研究表明,头颈部调强放射治疗(IMRT)对腮腺有明显的保护作用。与常规放疗相比,IMRT放疗后严重口干发生率显著下降,放疗后唾液流率影响降低,在肿瘤放射疗效不受影响的前提下,为解决放疗口干症带来了希望。本文就放射剂量-腮腺体积与腮腺唾液流率关系、IMRT放疗靶区勾画的改进、腮腺放射耐受剂量、口干的主客观评价标准等问题进行了阐述。认为如果把腮腺、下颌下腺和口腔黏膜的小唾液腺作为IMRT的保护目标,可能是一个更好的预防放疗后口干症的治疗方式。
Reducing postradiation xerostomia by intensity-modulated radiation therapy （IMRT） in head and neck cancer is updated here. Several studies have shown the superiority of IMRT over the conventional technique with respect to a reduction in severe xerostomia rate and an improvement in saliva flow without compromising tumor control. The degree of xerostomia and degression of saliva flow rate depends on the radiation dose and the salivary gland volume irradiated. The new approach of target delineation, exact threshold of radiation dose for parotid gland function, subjective and objective standard for xerostomia evaluation are also commented. Sparing the major （parotid and submandibular glands） and minor salivary glands at the same time during IMRT maybe more effective in prevention of postradiation xerostomia. Supported by Shanghai Leading Academic Discipline Project（Grant No.Y0203）.
出处
《上海口腔医学》
CAS
CSCD
2008年第5期540-544,共5页
Shanghai Journal of Stomatology
基金
上海市重点(优势)学科建设项目(Y0203)~~
关键词
头颈部癌
调强放射治疗
放疗后口干症
Head and neck cancer
Intensity modulated radiotherapy
Postradiation xerostomia
