摘要
目的:观察银杏达莫注射液对高血压肾损害患者尿蛋白的疗效。方法:采用前瞻性、随机对照试验。入选研究的患者55例,随机分为3组,A组19例,服用依那普利片,10mg/d;B组18例,给予银杏达莫注射液,20ml/d,加入生理盐水250ml静脉滴注;C组18例给予银杏达莫注射液,20ml/d,加入生理盐水250ml静脉滴注,同时服用依那普利10mg/d。疗程1个月。观察期间受试者血压控制在140/90mmHg左右,治疗过程中检测血常规、尿常规、24h尿蛋白定量、肾功能、血肌酐、血电解质,并记录血压及不良反应情况。结果:患者治疗前尿蛋白定量为(2.08±0.53)g/24h,A、B、C组治疗1个月后尿蛋白分别(1.67±0.36)g/24h(P<0.05)、(1.23±0.31)g/24h(P<0.01)、(0.81±0.35)g/24h(P<0.01)。结论:银杏达莫注射液可显著减少高血压肾损害患者蛋白尿并保护肾功能。
Objective：To evaluate efficacy of Ginkqo-damole injection in treating patients with microalbuminuri a of hypertensive renal lesion.Methods：A prospective,randomized controlled trial.The study selected patients 55 cases were randomly divided into three groups：Group A 19 cases,taken the ＂enalapril-10 mg/d＂;group B 18 cases,given Ginkqo-damole injection of 20 ml/d,joined NS 250 ml infusion;group C 18 cases to Ginkqo-damole injection of 20 ml/d,by adding intravenous saline 250 ml,while taking enalapril 10 mg/d.Course a month,during the observation of blood pressure control subjects in the 140/90 mmHg about the course of treatment of blood,urine routine,24-hour urinary protein excretion,renal function,serum creatinine,blood electrolyte,and recorded blood pressure and adverse reactions.Result：The patients before treatment for urinary protein excretion（2.08 ± 0.53）g/24 h,A,B,C group treatment in one month urine protein,respectively（1.67±0.36）g/24 h（P〈0.05）,（1.23±0.31）g/24 h（P〈0.01）,（0.81±0.35）g/24 h（P〈0.01）.Conclusion：Ginkqo-damole injection can significantly reduce kidney damage in patients with hypertension and proteinuria protect renal function.
出处
《新疆医科大学学报》
CAS
2008年第9期1192-1194,共3页
Journal of Xinjiang Medical University
关键词
银杏达莫
依那普利
蛋白尿
高血压肾损害
ginkqo-damole
enalapril
microalbuminuria
hypertensive renal lesion
