摘要
目的动态观察乌司他丁对急性重症胰腺炎（SAP）患者血清前炎症细胞因子TNF—α、IL-6的水平的影响及治疗机制。方法随机将78例SAP患者分成乌司他丁治疗组及非乌司他丁治疗组；在患者入院24h内以及治疗7d后检测其血清中TNF—α、IL-6水平。结果SAP患者TNF—α、IL-6较健康对照组均显著升高（P〈0．05），治疗7d后两组SAP患者TNF—α、IL-6均降低（P〈0．05），但乌司他丁治疗组下降更明显（P〈0．05）。结论乌司他丁可降低SAP患者前炎症性细胞因子水平。
Objective To evaluate the therapeutic effects of ulinastatin on seserum levels of proinflammatory cytokines in patients with severe acute pancreatitis（SAP）. Methods 78 SAP patients were randomized into two groups：a treating group with ulinastatin and a control - treating group. All eases were observed for 7 days. The seserum levels of tumor necrosis factor - α （ TNF - α） , interleukine 6 （ IL - 6 ） were measured. Results （1）The seserum levels of TNF - α, IL - 6 and LPS were significantly higher in SAP patients （ P 〈 0. 05 ）. （2）After being treated for one week,the seserum levels of TNF - α and IL - 6 were significantly decreased in ulinastatin treatment group than those in standard treatment group （ P 〈 0. 05 ）. Conclusion Ulinastatin is beneficial to SAP patients,by reducing proinflammatory cytokines levels in seserum.
出处
《中国实用医刊》
2008年第20期17-18,共2页
Chinese Journal of Practical Medicine
