摘要
目的：评价不同治则组方药物对老龄小鼠机体状况的改善程度。方法：对照观察补肾方、益气方、活血方水提物灌胃对老龄小鼠自由基代谢、应激能力及脾淋巴细胞增殖的影响。结果：①补肾方和益气方均能提高谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）、超氧化物歧化酶（ＳＯＤ）活性、降低过氧化脂质（ＬＰＯ）及脑脂褐素（Ｌｉｐｏｆｕｓｃｉｎ）含量，而活血方仅能提高ＳＯＤ活性和降低脑脂褐素含量。②三方均能提高小鼠在寒冷条件下的生存时间，益气方和补肾方还能提高小鼠耐缺氧生存时间。③三方对小鼠免疫反应均有调节作用。结论：三方均有一定的改善衰老效应，其中补肾方与益气方作用效果相当，均优于活血方。
Objective: To evaluate the effects of different Chinese medical formulae (Bushen formula, Yiqi formula and Huoxue formula) on health of senile mice. Methods: After the senile mice were orally administered the water extracts of the above-mentioned three formulae, the effects of different formulae on metabolism of free radicals, stress function and immunological function were studied. Results: 1) Both Bushen and Yiqi formulae enhanced the activity of glutathione peroxidase and superoxide desmutase (SOD) and decreased the contents of lipoperoxide (LPO) in hematoplasma and lipofusein in brain tissue homogenate. Whereas Huoxue formula only enhanced the activity of SOD and decreased the content of lipofusein in brain tissue homogenate. 2) All the formulae significantly prolonged the life term of mice in frigid environment and the first two did this even under hypoxic condition. 3) All the formulae exerted marked regulative effects on immune reaction. Conclusion: All the formulae can exert antisenility effects in senile mice and the first two are better than the last.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1997年第6期541-543,共3页
Journal of Third Military Medical University
关键词
补肾方
益气方
活血方
抗衰老药物
中药
Bushen formula
Yiqi formula
Huoxue formula
antisenility
mouse
