摘要
在４２１例中国人中应用肾素基因的一个四核苷酸〔ＡＣＡＧ〕串列重复顺序多态标记（Ｓｉｍｐｌｅｔａｎｄｅｍｒｅｐｅａｔｐｏｌｙｍｏｒｐｈｉｓｍ，ＳＴＲＰ）研究肾素（ＲＥＮ）基因与中国人２型糖尿病、冠心病及高血压以及糖尿病肾病、糖尿病视网膜病变的相关情况。中国人肾素基因的〔ＡＣＡＧ〕ｎ＿ＳＴＲＰ基因型中以４／４型，等位基因中以４型（ＡＣＡＧ重复次数＝８）为最多见。〔ＡＣＡＧ〕ｎ＿ＳＴＲＰ频率分布存在种族间差异。在２型糖尿病、冠心病、高血压间及各组与对照组间以及２型糖尿病中有或无糖尿病肾病、视网膜病变组间肾素基因〔ＡＣＡＧ〕ｎ＿ＳＴＲＰ频率分布均无明显差异。结果表明：中国人的２型糖尿病及糖尿病微血管病变以及冠心病、高血压的遗传因素中。
By using a tetranucleotide tandem repeat polymorphic marker ((ACAG)n_STRP), the association of renin gene (REN) with type 2 diabetes mellitus (DM) as well as diabetic nephropathy (DN), retinopathy (DR), coronary heart disease (CHD) and hypertension (HTN) was conducted among 421 Chinese subjects. The most frequent genotype and allele of REN (ACAG)n_STRP in Chinese are genotype 4/4 and allele 4(number of (ACAG) repeat=8). The frequency distribution of REN (ACAG)n_STRP showed significant difference among ethnic groups, but in type 2 DM no differences were observed in comparisons between groups of DM、CHD and HTN and controls, nor between DM patients with or without DN or DR. The results suggest that REN is not a major contributor to the genetic bases for DM and diabetic microangiopathy, CHD and HTN in Chinese.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1997年第4期206-209,共4页
Chinese Journal of Endocrinology and Metabolism
关键词
肾素基因
糖尿病
冠心病
高血压
相关性
Renin gene
Type 2 diabetes mellitus
Coronary heart disease
Hypertension
Diabetic nephropathy
Diabetic retinopathy
