摘要
目的以明胶为载体材料,制备5-FU缓释微球,研究5-FU缓释微球腹腔内给药后的5-FU药代动力学变化、组织中的分布及腹腔液中的药物浓度。方法通过动物实验,采用高效液相色谱法测定5-FU缓释微球腹腔内给药后,药物的释放速度、腹腔液浓度及在组织中的分布。结果5-FU缓释微球腹腔内给药后,可使5-FU缓慢持续释放,腹腔液浓度明显高于组织及血药浓度,利用已建立的标准曲线,采用3p97药代动力学软件处理,证明腹腔内给药时曲线下面积(AUC)5-FU缓释微球组明显高于5-FU原料药组。结论7d后5-FU缓释微球在腹腔内仍可保持有效抑癌浓度,其分布主要在腹腔中。
Objective To study the medicine dynamics, distribution in tissue and abdominal cavity fluid concentration of 5-FU after giving intraperitoneal by using a gelatin carrier to be made 5-FU slowing-release microballoons. Methods 5-FU slowing-release microballoons medicine release speed, tissue distributing and the concentration in abdominal cavity fluid were measured by high performance liquid chromatography. Results 5-FU wrapped by gelatin were slowly released. The concentration in abdominal cavity fluid was obviously higher than that in tissue or in blood. Using established standard curve line, it was proved that in body area under curve （AUC） of 5-FU slowing-release microballoons group was obviously higher than that of simple 5-FU injection group, analyzed by 3p97 pharmacokinetic software management. Conclusion 5-FU enwrapped by gelatin can retain an effective anticancer activity concentration in abdominal cavity 7 days after giving intraperitoneal and it is distributed mostly in abdominal cavity.
出处
《中国普外基础与临床杂志》
CAS
2008年第10期748-750,共3页
Chinese Journal of Bases and Clinics In General Surgery
关键词
5-FU缓释微球
腹腔种植
癌细胞
5-FU slowing-release microballoons Intraperitoneal plant Tumor cell
