摘要
目的通过检测子宫内膜异位症(EMs)患者血清及腹腔液中血小板衍生生长因子(PDGF)、血管细胞粘附分子-(VCAM-1)浓度,探讨PDGF和VCAM-1在EMs发病中的作用。方法选取手术后病理证实为EMs的40例患者为EMs组,其中I^II期17例,III^IV23例;非EMs组20例作为对照组。应用酶联免疫吸附法(ELISA)检测血清及腹腔液中PDGF和VCAM-1水平。结果EMs组血清及腹腔液中PDGF、VCAM-1水平均明显高于对照组(P<0.01)。随EMs期别的增加,其血清和腹腔液中PDGF、VCAM-1含量呈上升趋势;EMsIII^IV期水平显著高于I^II期(P<0.05)。EMs患者PDGF与VCAM-1呈正相关性(P<0.05)。结论EMs患者PDGF、VCAM-1表达水平升高,在EMs的发生发展中具有重要作用。
Objective：To detect the concentrations of platelet derived growth adhesion molecule-1 （VCAM-1） in sera and peritoneal fluid of patients possible role in the development of endometriosis. factor （PDGF）, vascular cellular with endometriosis and study their Methods： Forty patients with endometriosis pathologically diagnosed after operation were selected as endometriosis group, with 17 patients at stageⅠ-Ⅱ and 23 at stage Ⅲ-Ⅳ. Twenty patients without endometriosis were as control. The levels of PDGF, VCAM-1 in their sera and peritoneal fluid were measured by the method of ELISA. Results： It was found that the expressions of both PDGF and VCAM-1 in patients with endometriosis were significantly higher than those in controls （P〈0.01）. The expression of PDGF, VCAM-1 in sera and peritoneal fluid correlated with the stage of the disease, with the higher levels of both PDGF and VCAM-1 at stage Ⅲ-Ⅳ than at stageⅠ-Ⅱ（P〈0.05）. There was a positive correlation between PDGF and VCAM-1 levels in the patients with endometriosis （P〈0. 05）. Conclusions：The expressions of PDGF and VCAM 1 are elevated in women with endometriosis, which may play an important role in the pathogenesis of endometriosis.
出处
《生殖医学杂志》
CAS
2008年第5期342-345,共4页
Journal of Reproductive Medicine
基金
河北省计划生育委员会科技计划项目(2005-002)
