摘要
目的：研究肿瘤坏死因子（TNF-α）在复发性口腔溃疡患者中的变化及临床意义．方法：用双抗体夹心ELISA法对复发性口腔溃疡患者56例（男18，女38，年龄17～60岁）血清中TNF-α的含量进行了检测，8例进行病理检查，并以25例健康人血清做对照．结果：在8例病理切片中7例显示为以淋巴细胞、浆细胞及单核巨噬细胞侵润为主的炎症，1例为增生．复发性口腔溃疡56例患者血清中TNF-a的平均含量（51．4±6．6）μg／L比健康人（8．8±1．2）μg／L明显升高（P〈0．01），且中型（n=28，P〈0．05）和重型（n=14，P〈0．01）TNF-a平均含量均明显高于轻型（n=14，P〈0．01），即重型〉中型〉轻型．结论：复发性口腔溃疡患者血清TNF-a的含量可明显增高，提示TNF-a参与了其病理过程．
AIM： To investigate the changes of tumor necrosis factor α （TNF-α） in patients with recurrent oral ulcer （ROU） and its clinical significance. METHODS ： Serum levels of TNF-α in 56 patients （ male 18, female 38, aged 17-60 years） with ROU were determined by double-antibody sandwich ELISA, and 8 of them underwent pathological examination. Twenty-five healthy individuals served as controls. RESULTS： Of the 8 cases undergoing pathological examination, 7 showed the inflammatory infiltration of lymphocytes, plasma cells and mononuclear macrophages, and the other 1 showed hyperplasia. The mean serum TNF-α level in ROU patients （51.4 ± 6.6） μg/L was significantly higher than that in the controls（8.8 ± 1.2） μg/L （ P 〈0.01 ） and the serum TNF-α level of patients with moderate （ n = 28, P 〈 0.05） and severe （n = 14, P 〈0.01） ROU was significantly higher than that of patients with mild ROU （ n = 14, P 〈 0.01 ）. CONCLUSION： The serum TNF-α level in ROU patients is significantly increased, which indicates that TNF-α may play a role in the pathogenesis of ROU.
出处
《第四军医大学学报》
CAS
北大核心
2006年第6期530-532,共3页
Journal of the Fourth Military Medical University
关键词
复发
口腔溃疡
肿瘤坏死因子
血清
病理学
recurrence, oral ulcer
tumor necrosis factor
serum
pathology
