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合成6-氟-2-甲基茚酮的新方法 被引量：2

A New Synthesis Method of 6-Fluoro-2-methylindanone
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摘要 对氟氯苄与甲基丙二酸二乙酯经缩合、碱性水解、脱羧、SOCl2酰氯化、分子内Friedel-Crafts酰基化等反应合成非甾体抗炎药舒林酸的中间体——6-氟-2-甲基茚酮,总收率57.0%,其结构经1H NMR,GC-MS和元素分析表征。 An intermediate of Sulindae, 6-fluoro-2-methylindanone, was synthesized from 4-fluorobenzyl chloride via condensation with diethyl methyl malonate, hydrolysis in the presence of KOH, decarboxylation, aeyl chlorination with SOC12, and intermolecular Friedel - Crafts reaction. The overall yield was up to 57.0%. The structure was characterized by ^1H NMR, GC-MS and elemental analysis.
作者 戴立言 贺电 王晓钟 陈英奇
机构地区 浙江大学材料与化工学院制药工程研究所
出处 《合成化学》 CAS CSCD 2008年第5期614-616,共3页 Chinese Journal of Synthetic Chemistry
关键词 茚酮 Friedel—Crafts反应 缩合 合成 indanone Friedel - Crafts reaction condensation synthesis
分类号 TQ242.2 [化学工程—有机化工] TB333 [一般工业技术—材料科学与工程]
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同被引文献33

  • 1陈锦露,张芝平,张一宾.新颖氨基甲酸酯类杀虫剂——茚虫威(indoxacarb)的合成与应用[J].浙江化工,2005,36(1):30-32. 被引量：21
  • 2魏荣卿,汪海萍,沈斌,刘晓宁,欧阳平凯.硝基苯对傅克酰基化反应制备羧基化聚苯乙烯的影响[J].化工学报,2005,56(7):1230-1235. 被引量：8
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  • 6Cui D M, Zhang C, Kawamura M, et al. Synthesis of 1-indanones by intramolecular Friedel-Crafts reaction of 3-arylpropionic acids catalyzed by Tb(OTf)3 [J]. Tetrahedron Lett., 2004,45 (8): 1741 - 1745.
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合成化学
2008年 第5期

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