摘要
目的了解奥扎格雷对糖尿病足浅表溃疡愈合的影响。方法糖尿病足1级病人96例，随机分为对照组和奥扎格雷组，各48例，均给予降糖治疗和甲钴胺素1500μg／d静滴。在此基础上，奥扎格雷组给予奥扎格雷钠80mg／d静滴，共3周。测定两组病人治疗前后血压、血糖、血脂、血液流变学参数和胫、腓神经运动传导速度，观察溃疡愈合时间。结果与治疗前比较，治疗后对照组收缩压、舒张压、FPG、TG、Tch、LDL-C水平均显著降低，HDL-C水平和胫、腓神经传导速度显著升高，差异有显著性（t=2.698-2.812，P〈0.01）；奥扎格雷组治疗后收缩压、舒张压、FPG、TG、Tch、LDL-C水平均显著降低，HDL-C水平和胫、腓神经传导速度显著升高，差异有显著性（t=2.710-2.825，P〈0.01）。治疗后上述指标两组之间比较差异无显著性（P〉0．05）。治疗后奥扎格雷组1、3min和最大血小板聚集率显著低于对照组（t=2.730-2.848，P〈0.01）；糖尿病足溃疡愈合时间显著短于对照组（t=2.225，P〈0.05）。结论奥扎格雷能改善糖尿病足病人血小板聚集性并缩短溃疡愈合时间。
Objective To assess the effect of ozagrel on superfieial ulcer of diabetic foot. Methods Ninety-six patients with grade 1 diabetic foot were evenly divided into control group and ozagrel group. Hypoglycemic treatment and intravenous drip of meeobalamin （1500μg）, once a day, were given to both groups. For ozagrel group, intravenous drip of ozagrel sodium （80μg） was added daily for three weeks. Fasting plasma glucose （FPG）, lipid, haemorheological parameters, tibial and peroneal nerve motorial conduction velocity （T-PNMCV）, the ulcer healing time were observed. Results Compared with before treatment, in control group： systolic and diastolic pressure, FPG, TG, Tch, and LDL-C were decreased, HDL-C and T-PNMCV increased （t=2.698-2.812,P〈0.01）; in ozagrel group; blood pressure, FPG, TG, Tch, and LDC-C decreased, HDL-C and T-PNMCV increased （t=2.710-2.825,P〈0.01）. There ware no significant differences of above parameters between the two groups. After treatment, one and three minutes and maximum platelet aggregation rates were lower in ozagrel group than that in the control （t=2.736-2. 848,P〈0.01）. The ulcer healing time was shorter in ozagrel group （t=2.225,P〈0.05）. Conclusion Ozagrel can improve platelet aggregation and shorten the healing time of ulcer in patients with diabetic foot.
出处
《青岛大学医学院学报》
CAS
2008年第5期406-408,共3页
Acta Academiae Medicinae Qingdao Universitatis
