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星形胶质细胞对神经元作用的研究进展 被引量：5

Research progress——the role of astrocyte in neuronal functions
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摘要 星形胶质细胞能够释放多种胶质细胞源性递质,调节突触信号的传递;释放的雌激素、凝血栓蛋白、IL-1β和IL-6能够诱导突触的形成和神经干细胞的神经发生。此外,星形胶质细胞还能为神经元提供重要的营养和保护作用。星形胶质细胞可能是治疗某些神经系统疾病的新靶点。 Astrocytes can regulate synaptic transmission by releasing gliotransmitter,and also can promote synaptogenesis and neurogenesis by releasing estrogen,thrombospondins,IL-1β and IL-6. Astrocytes may play critical roles in neural nutrition and neuroprotection,so that it might be a new target for treatment of certain central nervous system diseases.
作者 王建彪(综述) 竺可青(综述)
机构地区 浙江大学医学院病理学与法医学研究所
出处 《浙江大学学报（医学版）》 CAS CSCD 2008年第5期531-536,共6页 Journal of Zhejiang University(Medical Sciences)
基金 国家自然科学基金(30770677)
关键词 星形细胞/生理学 神经元/生理学 中枢神经系统/生理学 Astrocytes/physiol Neurons/physiol Central nervous system/physiol
分类号 R388 [医药卫生—医学寄生虫学]
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参考文献31

  • 1HAYDON P G, CARMIGNOTO G. Astrocyte control of synaptic transmission and neurovascular coupling[J]. Physiol Rev, 2006,86 (3) :1009-1031.
  • 2TODD A,FIACCO K D M. Astrocyte calcium elevations : properties,propagation ,and effects on brain signaling[J]. Gila, 2006,54 (7) : 676-690.
  • 3SUADICANI S O ,BROSNAN C F ,SCEMES E. P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2 + signaling [J]. J Neurosci, 2006, 26 (5): 1378- 1385.
  • 4JOURDAIN P, BERGERSEN LH, BHAUKAURALLY K, et al. Glutamate exocytosis from astrocytes controls synaptic strength [J]. Nat Neurosci, 2007, 10(3): 331- 339.
  • 5FIACCO T A,MCCARTHY K D. Intracellular astrocyte calcium waves in situ increase the frequency of spontaneous AMPA receptor currents in CA1 pyramidal neurons [J].J Neurosci, 2004,24(3) : 722-732
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  • 7LIU QS XQ, KANG J, et al. Astrocyte activation of presynaptic metahotropic glutamate receptors modulates hippocampal inhibitory synaptic transmission[J].Neuron Glia Biol, 2004,1 (4) :307-316.
  • 8MOTHET J-P, POLLEGIONI L, OUANOUNOU G,et al. Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine [J]. Pro Natl Acad Sci,2005,102(15) :5606 -5611.
  • 9YANG S, QIAO H, WEN L, et al. D-serine enhances impaired long-term potentiation in CA1 subfield of hippocampal slices from aged senescence-accelerated mouse prone/8 [ J ]. Neurosci Lett, 2005,379(1) : 7-12.
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浙江大学学报（医学版）
2008年 第5期

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