摘要
目的:回顾性研究血清乙型肝炎病毒DNA(hepatitis B virus DNA,HBV-DNA)载量与乙型肝炎病毒相关性肾炎(hepatitis B virus associated-glomerulonephritis,HBV-GN)肾脏病理演变的相关性。方法:根据血清HBV-DNA载量,将41例HBV-GN患者分为3组,分别为低度复制组、中度复制组、高度复制组。分析其中35例膜性肾病患者病理分期与病毒DNA复制的相关性;根据免疫组织化学染色结果,比较HBV-DNA复制水平对肾组织HBV抗原沉积的影响,以及HBV抗原沉积对膜性肾病病理变化的影响。结果:随着HBV-DNA复制增加,35例膜性肾病患者的肾脏病理损害逐渐加重,DNA定量水平与病理变化之间存在相关性;随着HBV-DNA复制的增加,HBV抗原在肾小球沉积的数量增加;随着HBV抗原沉积的增加,膜性肾病患者的肾脏病理损害加重。结论:随着HBV-DNA复制增多,乙肝病毒抗原成分沉积增多,肾脏病理损害逐渐加重,其变化存在相关性。
Objective To investigate the correlation between the content of hepatitis B virus DNA（HBV-DNA） in the serum and the pathologic change in hepatitis B virus associated-glomerulonephritis （HBV-GN）. Methods Forty one HBV-GN patients were divided into 3 groups by the content of HBV-DNA in the serum：low replicate group, midrange replicate group, and high replicate group. The relationship with the content of HBV-DNA in the serum and pathologic stage or change was analyzed in 35 membranous glomerulopathy patients; Effect of the content of hepatitis B virus DNA in the serum on HBVAg deposition in glomeruli of kidney was examined by immunohistochemistry; Effect of HBVAg deposition on pathologic change was observed in membranous glomerulopathy patients. Results With the multiplication of HBV-DNA in the serum, the pathologic lesion was aggravating from Stage Ⅰ to Stage Ⅲ in membranous glomerulopathy patients; the deposition of HBVAg in glomeruli of kidney was increasing ; with the increasing of deposition of HBVAg in glomeruli of kidney, the pathologic lesion was aggravating in membranous glomerulopathy patients. Conclusion With the multiplication of HBV-DNA in the serum, the deposition of HBVAg in glomeruli of kidney increases, and the pathologic lesion aggravates, which have significant correlation.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2008年第9期857-860,共4页
Journal of Central South University ：Medical Science
