摘要
目的探讨选择性雌激素受体调节剂雷洛昔芬对去卵巢大鼠血浆纤维蛋白原的影响。方法40只12周龄雌性SD大鼠随机分为5组,每组8只。(1)去卵巢组(Ovariectomy,OVX):切除大鼠双侧卵巢建立绝经后模型,给予等量生理盐水灌胃;(2)假手术对照组(Control,C):只打开腹腔未切除双侧卵巢,给予等量生理盐水灌胃;(3)雌激素组(Ovariectomy+Estrogen,E):切除大鼠双侧卵巢,给予雌激素(倍美力,1mg/kg·d)灌胃治疗;(4)小剂量雷洛昔芬组(Ovariectomy+Raloxifene,Rs):切除大鼠双侧卵巢,给予雷洛昔芬(易维特,1mg/kg·d)灌胃治疗;(5)大剂量雷洛昔芬组(Ovariectomy+Raloxifene,Rl):切除大鼠双侧卵巢,给予雷洛昔芬([易维特,3mg(/kg·d)灌胃治疗。治疗3个月后,测量治疗后各组血浆纤维蛋白原的变化。结果去卵巢组血清雌二醇水平明显下降,显著低于假手术对照组。雌激素或雷洛昔芬治疗后血清雌二醇水平都上升,接近假手术对照组(OVX:36.69±6.91比C:248.32±32.51比E:240.89±29.44比Rs:239.56±25.73比Rl:243.48±27.62pg/mL,P<0.01)。去卵巢组的血浆纤维蛋白原浓度显著高于假手术对照组和雷洛昔芬组。雌激素组纤维蛋白原的浓度也升高,与假手术对照组比较有统计学意义。雷洛昔芬治疗后纤维蛋白原下降,低于去卵巢组和雌激素组(OVX:4.25±0.43比C:1.76±0.20比E:3.46±0.31比Rs:1.63±0.19比Rl:1.41±0.16g/L,P<0.05)。结论雌性SD大鼠双侧卵巢切除后,纤维蛋白原水平升高。雌激素治疗不能降低纤维蛋白原水平反而升高其水平,而雷洛昔芬能降低纤维蛋白原水平。
Objective To investigate the effect of raloxifene,a selective estrogen receptor modulator,on fibrinogen in ovariectomized rats. Methods Forty twelve-week-old female Spragne-Dawley rats were randomly divided into five groups：（ 1 ）ovariectomy（OVX）;（2）sham operation（C ） ; （3）ovariectomy ＋ estrogen[（ 1mg/（kg·d）, E]; （4）ovariectomy ＋ small dose raloxifene[1mg/（kg·d）, Rs]; （5）ovariectomy ＋ large dose raloxifene[3mg/（kg·d）,Rl]. Serum estradiol and fibrinogen were measured before and after three-month treatment. Results Serum estradiol concentration was significantly lower in ovarieetomized rats than that in sham operated animals. Serum estradiol was increased after the treat- ment of raloxifene（OVX：36.69 ± 6.91 vs C：248.32 ± 32.51 vs E：240.89 ± 29.44 vs Rs：239.56 ± 25.73 vs Rl：243.48 ± 27.62 pg/ml,P〈 0.01 ）. The concentration of serum fibrinogen（Fg）was increased in OVX and E groups,raloxifene could decreased Fg（OVX：4.25 ± 0.43 vs C： 1.76 ± 0.20 vs E：3.46 ± 0.31 vs Rs： 1.63 ± 0.19 vs Rl： 1.41 ± 0.16g/L,P〈 0.05）. Conclusion The concentration of serum fibrinogen increased after ovariectomy, raloxifene could decreased fibrinogen.
出处
《中国现代医生》
2008年第29期1-3,共3页
China Modern Doctor
