摘要
目的:观察养肝益水颗粒对高血压早期肾损害患者尿清蛋白排泄率(urinary albumin ex-cretion ratio,UAER)、尿微量清蛋白(microalbuminuria,MA)、β2微球蛋白(β2-microglobulin,β2-MG)、α1微球蛋白(α1-microglobulin,α1-MG)、转铁蛋白(transferrin,TRF)、免疫球蛋白G(i mmu-noglobulin G,IgGu)的影响。方法:选择80例符合中医辨证的高血压早期肾损害患者,随机分为治疗组和对照组。两组均给予常规降压治疗。治疗组同时加服养肝益水颗粒。两组疗程均为4周。分别于治疗前和治疗4周后进行UAER、MA、α1-MG、β2-MG、TRF、IgGu测定。结果:治疗后两组UAER、MA、α1-MG、β2-MG、TRF、IgGu水平均显著下降,且治疗组与对照组比较,上述指标的差异具有显著性(P<0.05,P<0.01)。结论:养肝益水颗粒具有减少高血压早期肾损害尿微量蛋白排出的作用。
Objective： To observe the clinical effects of YangganYishui （YGYS） Granule on the levels of urinary albumin excretion ratio（ UAER）, microalbuminuria（MA）,β2-microglobulin（β2-MG）, α-microglob-ulin（α1 -MG）, transferrin（TRF）, immunoglobulin G（IgGu） in treating early renal damage induced by essential hypertension （EH）. Methods： Eighty EH patients with early renal damage were randomly divided into 2 groups： treatment group （n=40） and control group （n=40）. Both two groups were treated with conventionally therapeutic methods of antihypertensives for 4 weeks. Simultaneously, the YGYS Granule was administrated in the treatment group. The levels of UAER,MA,β2-MG,α1-MG,TRF,IgGu were measured and compared before treatment and 4 weeks after treatment. Results： After treatment, the levels of UAER,MA,β2-MG,α1-MG,TRF, IgGu in both group decreased significantly, and there were significant differences in above mentioned indexes between control group and treatment group（P〈0, 05, or P〈0.01）. Conclusion： YGYS Granule possesses the effect of reducing the excretion of urine microalbumin in patients with EH-induced early renal damage.
出处
《安徽中医学院学报》
CAS
2008年第5期23-25,共3页
Journal of Anhui Traditional Chinese Medical College
关键词
原发性高血压
早期肾损害
尿微量蛋白
养肝益水颗粒
Essential hypertension
Early renal damage
Urine microalbumin
Yanggan Yishui Granule
