摘要
目的:观察糖肾通络方治疗早期糖尿病肾病(DN)的临床疗效及作用机制。方法:将45例早期DN患者随机分为糖肾通络方组25例,苯那普利组20例,观察治疗前后中医证候积分,检测治疗前后血中糖化血红蛋白(HbA1c)、内生肌酐清除率(CCr)、空腹血糖(FBG)、三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、Ⅳ型胶原(Ⅳ-C)及尿微量清蛋白排泄率(UAER)水平。结果:两组治疗后中医证候积分糖肾通络方组较苯那普利组显著降低(P<0.01);临床总有效率糖肾通络方组为84.00%,苯那普利组为55.00%,两组总有效率比较,差异具有显著性(P<0.05);治疗后糖肾通络方组HbA1c、FBG、TG、TC、LDL-C、Ⅳ-C、UAER均较苯那普利组显著降低(P<0.01),血HDL-C含量较苯那普利组显著升高(P<0.01)。结论:糖肾通络方具有改善临床症状,调节血糖、血脂,改善肾功能的作用,其机制与阻止或抑制Ⅳ-C分泌,促进Ⅳ-C降解,改善肾小球基膜及系膜细胞基质有关。
Objective： To explore the effects of Tangshen Tongluo（TSTL） Recipe on Ⅳ collagen（Ⅳ-C）and urine micro albumen excretion rate （UAER）in patients with early diabetic nephropathy （DN）. Methods： Forty-five cases of early DN patients were randomly divided into TSTL Recipe group （25 cases） and Lotensin group （20 cases）. Before and after the treatment with TSTL Recipe and Lotensin, the scores of TCM syndrome, the serum levels of Cr, CCr, FBG, Ⅳ-C, TC, TG, HDL-C, LDL-C and UAER were detected in the DN patients. Results： After the treatment by TSTL Recipe and Lotensin, the scores of TCM syndrome, the serum levels of FBG, Ⅳ-C, TC , TG, LDL-C and UAER significantly decreased in the TSTL Recipe group than those in the I.otensin group （P〈0.01）, and the level of HDL-C significantly in- creased than that in the Lotensin group （P〈0.01） . The total effective rate in the TSTL Recipe group was 84.00%, being significantly higher than that in the Lotensin group （50.00%）. Conclusion： TSTL Recipe has effects of regulating lipid metabolism and blood glucose,improving main clinical symptoms and renal function. The mechanism might be related with inhibiting the secretion of Ⅳ-C,promoting the degradation of Ⅳ-C,and improving the cell matrix of glomerular basement membrane and intercapillary.
出处
《安徽中医学院学报》
CAS
2008年第5期19-22,共4页
Journal of Anhui Traditional Chinese Medical College
关键词
糖尿病肾病
尿微量清蛋白排泄率
Ⅳ型胶原
肾功能
糖肾通络方
Diabetic nephropathy
Urine micro albumen excretion rate
Ⅳ collagen
Renal function
Tangshen Tongluo Recipe
