摘要
本实验用增殖细胞核抗原（ＰＣＮＡ）单抗ＰＣ１０及雌激素受体（ＥＲ）多抗对７０例肝细胞性肝场组织（高分化型４９例，低分化型２１例）作免疫组织化学染色，观察不同分化肝场组织ＰＣＮＡ表达及ＥＲ与肿瘤增殖的关系。结果显示５３例肝癌组织ＰＣＮＡ阳性，其中高分化３７例（７５．５％），低分化１６例（７６．２％）．二者阳性率无明显差异，ＥＲ染色２４例阳性，包括高分化１３例（２６．５％），低分化１１例（５２．４％）．后者阳性率显著高于前者（Ｐ＜０．０５），且ＥＲ表达与ＰＣＮＡ正相关（Ｐ＜０．０５）。以上结果提示仅凭ＰＣＮＡ判断肝癌分化程度及患者预后是不妥当的；雌激素系统可能对肝细胞性肝癌增殖有促进作用。
Proliferating cell nuclear antigen (PCNA) monoclonal antibody PC 10 and eatrogen receptor polyclonal antibody (ER) were appiled to 70 cases of hepatocellular carcinoma (HCC), including well - differentiated (WD) 49 cases and poorly -differentiated (PD) 21 cases,with immunocytochemical method to observe the proliferativeactivity in different types of HCC,and the relationship between the proliferation of HCC and ER.The resultsindicated that 53 cases were positive of PCNA. WD 37 cases and PD 16 caaes. Positive ratea of both (75.5% , 76.2% ) had no oarked difference. 24 cases were positive of BR, including WD 13 cases and PD 11 cases, The positive rate of PD (52.4% ) was higher than WD's (26.5%) (P<0.05) There was a positive correlation between PCNA and ER. (P<0.05) The results suggested that it is not suitable to ujdge the differentation and prognosis of HCC only by PCNA, and estrogen system probably promote the proliferation of HCC.
出处
《重庆医科大学学报》
CAS
CSCD
1997年第4期293-294,共2页
Journal of Chongqing Medical University
关键词
肝细胞性肝癌
增殖细胞核抗原
雌激素
肝肿瘤
Hepatocellular carcinoma
Proliferating cell nuclear antigen
Estrogen, lm- munohistochemistry
