摘要
目的:探讨川芎挥发油解热作用机理。方法:采用免疫组化方法研究川芎挥发油对啤酒酵母发热大鼠下丘脑组织COX-2蛋白表达的影响。结果:模型组大鼠下丘脑COX-2蛋白表达高于正常对照组(P<0.01),川芎挥发油高、中剂量组COX-2蛋白表达低于模型组(P<0.01或0.05),低剂量组与模型组相比无明显差异(P>0.05)。结论:川芎挥发油解热机理之一可能是抑制大鼠下丘脑COX-2的表达从而减少PGE2的产生使中枢体温调定点下调达解热效应。
Objective： to investigate the antipyretic mechanism of Essential oil of Ligusticum chuanxiong Holt （CH） . Methods： The expressions of COX -2 protein in hypothalamus of brewer＇s yeast - induced fever rats were checked using Immunohistochemistry. ResuLts： The expressions of COX -2 protein in hypotbalamus of model team are higher than normal team, expressions of teams of high and middle dose of CH are lower than model team, expression of team of low dose of CH has no obvious different with model team. Conclusion ： one of the anfipyretie mechanism of essential oil of Ligustieum ehuanxiong Hort. （CH） may be to inhibit the expression of COX - 2 protein in hypothalamus of rats, thereby reduce the content of PGE2 that lower the set point and produce anfipyrefie effect.
出处
《成都中医药大学学报》
2008年第3期38-39,共2页
Journal of Chengdu University of Traditional Chinese Medicine
基金
四川省科技厅科研基金(05JY029-045)
四川省教育厅科研基金(2003A044)资助
