摘要
采用沙土鼠双侧颈总动脉夹闭１０ｍｉｎ或２０ｍｉｎ后再灌７ｄ或１ｄ，造成脑缺血再灌损伤模型，观察阿司匹林铜对沙土鼠脑组织钙、水含量的影响，及对海马ＣＡ１区神经元迟发性损伤的保护作用．结果显示：阿司匹林铜（７．５ｍｇ／ｋｇ）即能减轻脑组织钙累积，剂量１５ｍｇ／ｋｇ能增加脑缺血后海马ＣＡＩ区的神经元密度．提示阿司匹林铜对缺血再灌脑组织损伤有一定的保护作用．
Cerebral ischemia injury model was produced by 10 min or 20 min occlusion of bilateral carotid arteries followed by 7 d or 1 d reperfusion in gerbils. Copper aspirin was observed for its effects on calcium and water contents in gerbil brain cortex and on protection from neuronally delayed injury in hippocamal CA 1 sector. The results indicated that copper aspirin (7 5 mg/kg) could reduce the calcium accumulation in brain cortex and that the dosage of 15 mg/kg could increase neural density in the posterior CA 1 sector of hippocampus. All this suggested that copper aspirin has neuroprotective effects on cerebral ischemia reperfusion injury.
出处
《昆明医学院学报》
1997年第3期14-17,共4页
Journal of Kunming Medical College
基金
云南省应用基础研究基金
关键词
阿司匹林铜
脑缺血
再灌注损伤
保护
Copper aspirin, Cerebral ischemia, Reperfusion, Neuronal density, Gerbils
