摘要
耐甲氧西林葡萄球菌是引起医院内感染的重要致病菌。为了解该菌的耐药情况，进而为临床预防与治疗提供依据，我们对８８株葡萄球菌进行了耐甲氧西林及耐其它１４种常用抗生素和产β－内酰胺酶的测定。结果：耐甲氧西林金黄色葡萄球菌检出率为５６％，耐甲氧西林凝固酶阴性葡萄球菌检出率为４７．６％；耐甲氧西林敏感葡萄球菌对１４种常用抗生素的耐药性及多重耐药性均高于甲氧西林敏感葡萄球菌；产β－内酰胺酶最高的是耐甲氧西林金黄色葡萄球菌，产酶率为９２．９％，最低的是甲氧西林敏感凝固酶阴性葡萄球菌，为３９．４％，说明产酶与耐药之间有一定关系。耐甲氧西林葡萄球菌对万古霉素、呋喃妥因敏感，提示这２种药可作为临床治疗该类菌的首选药物。
Methicillin resistant staphylococcus aureus is one of the important patholonic bacteria which cause nosocomial infection.In order to investigate the resistant antibiotic circumstances of this organism and hence provide foundations of prevention and treatment,we determined the resistant rates of 88 staphylococcus strains for methicillin and for other 14 kinds of commonly used antibiotics,and we determined the engendering β lactamase.The results showed that the isolation rate of methicillin resistant staphylococcus aureus (MRSA) was 56%;the rate of methicillin resistant staphylococcus coagulase negative (MRSCoN) was 47.6%;the resistance rate and the multi resistant rate of methicillin resistant staphylococcus(MRS) for the 14 kinds of antibiotics were higher as compared with those of methicillin sensitive (MSSA).Among all the tested strains,MRSA was the highest to engender β lactamase(92.9%);Methicillin sensitive staphylococcus coagulase negative (MSSCoN) was the lowest (39.4%).MRS was sensitive to vancomycin and furantoin.These suggest that when treating this bacterium,we should select these two antibiotics first.
出处
《华西医科大学学报》
CSCD
1997年第3期329-333,共5页
Journal of West China University of Medical Sciences
关键词
耐甲氧西林
金黄色葡萄球菌
耐药性
MRSA
Methicillin resistant Staphylococcus aureus(MRSA) Methicillin resistant staphylococcus coagulase negative (MRSCoN) Methicillin resistant staplyloco ccus (MRS) Methicillin sensitive staphylococcus (MSS) Resistant antibiotic
