期刊文献+

普伐他汀对慢性心力衰竭患者血浆NT-proBNP、CRP水平及心功能的影响 被引量:1

暂未订购
导出
摘要 将73例慢性心力衰竭(心衰)患者随机分为观察组和对照组,均予常规抗心衰治疗,观察组加服普伐他汀,疗程8周。治疗前后用彩超测定心功能指标[左心室射血分数(LVEF)、左心室舒张末期内径(LVDd)],ELISA法和散射比浊法测定血浆N-末端脑钠肽前体(NT-proBNP)、C反应蛋白(CRP)水平。结果治疗后观察组总有效率明显高于对照组,心功能指标LVEF明显升高、LVDd明显下降,血浆NT-proBNP、CRP水平均明显下降,P均<0.05;观察组血浆NT-proBNP与LVEF呈负相关(r=-0.72,P<0.05),与LVDd呈正相关(r=0.75,P<0.05);血浆CRP水平与LVDd呈正相关(r=0.31,P<0.05),与LVEF增加呈负相关(r=-0.387,P<0.05)。提示普伐他汀治疗慢性心衰效果确切,其主要作用机制为降低血浆NT-proBNP、CRP水平。
出处 《山东医药》 CAS 北大核心 2008年第26期64-65,共2页 Shandong Medical Journal
  • 相关文献

参考文献5

  • 1Selvais PL, Donckier JE, Robert A, et al. Cardiac natriuretic peptides for diagnosis and risk stratification in heart failure: influences of left ventricular dysfunction and coronary artery disease on cardiac hormonal activation [ J ]. Eur J Clin Invest, 1998, 28 (8) : 636- 642.
  • 2赖长春,高伟栋,李浙成,应显星,胡智星,童跃锋.慢性心力衰竭时脑钠肽和C反应蛋白水平及卡维地洛的疗效[J].岭南心血管病杂志,2007,13(5):340-343. 被引量:21
  • 3Odar-Cederlof I, Bjellerup P, Williams A, et al. Daily dialyses decrease plasma levels of brain natriuretic peptide (BNP) , a biomarker of left ventricular dysfunction [ J]. Hemodial Int, 2006, 10 (4) : 394- 398.
  • 4Troughton RW, Frampton CM, Yandle TG, et al Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations [ J ]. Lancet, 2000, 355 (9210) : 1126-1130.
  • 5Node K, Fujita M, Kitakaze M, et al. Short term statin therapy improves cardiac function and sympotms in patients with idiopathic dilated cardiomyopathy[ J ]. Circulation, 2003, 108 (7) : 839-843.

二级参考文献8

  • 1杜林林,王朝晖.卡维地洛对TNF-α诱导心肌细胞凋亡的保护作用[J].中国临床药理学与治疗学,2005,10(11):1286-1289. 被引量:1
  • 2[2]RICHARDS A M,DOUGHTY R,NICHOLLS MG,et al.Nerurohumoral prediction of benefit from carvedilol in ischemic left ventricular dysfunction[J].Circulation,1999,99 (6):786-792.
  • 3[3]GABAY C,KUSHNER I.Acute-phase proteins and other systemic responses to inflammation[J].N Engl J Med,1999,340 (6):448-454.
  • 4[4]SUFFREDINI A F,FROMM R E,PARKER M M,et al.The cardiovascular response of normal humans to the administration of endotoxin[J].N Engl J Med,1989,321(5):280-287.
  • 5[5]SAM F,SAWYER D B,CHANG D L,et al.Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart[J].Am J Physiol Heart Circ Physiol,2000,279 (1):H422-H428.
  • 6[6]ALONSO-MARTINEZ J L,LLORENTE-DIEZ B,ECHEGARAY-AGARA M,et al.C-reactive protein as a predictor of improvement and readmission in heart failure[J].Eur J Heart Fail,2002,49 (3):331-336.
  • 7[7]TORRE A G,KAPADIA S,BENEDICT C,et al.Proin flammatory cytokine levels in patients with depressed left ventricular ejection fraction:a report from the studies of left ventricular dysfunction (SOLVD)[J].Am Coll Cardiol,1996,27 (5):1201-1206.
  • 8慢性收缩性心力衰竭治疗建议[J].中华心血管病杂志,2002,30(1):7-23. 被引量:2410

共引文献20

同被引文献4

引证文献1

二级引证文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部