摘要
为了探讨重症肌无力（ＭＧ）患者红细胞免疫功能的变化，我们测定了２０１例ＭＧ患者外周血ＲＢＣ－Ｃ３ｂ受体花环率（ＲＢＣ－Ｃ３ｂＲＲ）和ＲＢＣ－ＩＣ花环率（ＲＢＣ－ＩＣＲ）和５０名正常人进行对照。结果为ＭＧ患者的ＲＢＣ－Ｃ３ｂＲＲ（７．５８±３．４％）明显低于正常对照组（１２．８７±５．０７％）（Ｐ＜０．０１），ＲＢＣ－ＩＣＲ（５．８３±４．６２％）稍高于正常对照组（５．０３±３．８４％）（Ｐ＞０．０５），ＭＧ全身型组ＲＢＣ－Ｃ３ｂＲＲ（５．２５±１．８５％）明显低于眼肌型组（８．５９±３．１９％）（Ｐ＜０．０１），强的松治疗前组（７．９８±４．０１％）与治疗后组（１１．６４±４．３５％）有明显差异（Ｐ＜０．０１），强的松治疗前后ＲＢＣ－ＩＣＲ的变化无统计学意义。上述结果表明ＭＧ患者红细胞免疫粘附功能低下与ＭＧ发病有一定的相关性。ＭＧ的发病不仅有体液免疫功能障碍，还可能有红细胞免疫功能障碍，我们的资料为ＭＧ免疫病原学发病机理提供了一项新的实验依据，也可为免疫治疗ＭＧ评定疗效提供客观辅助指标。
In attempt to investigate the changes of erythrocyte immunity function in myasthenia gravis (MG) patients, we have determined RBCC3b receptor rossette rate and RBCIC rossette rate in 50 controls and 201 cases with myasthenia gravis. The statistic analysis showed that RBCC3bRR in patients groups (7.58±3.04%) was significantly lower than that in controls (12.87±5.07%)(P<0.01);RBCICR(5.83±4.62%) slightly higher than that in controls (5.03±3.84%) (P>0.05), Among cases, RBCC3bRR in generalized type of MG (5.25±1.85%) was significantly lower than that in ocular type (8.59±3.19%)(P<0.01),and there was a significantly difference between pretreatment (7.98±4.01%) and posttreatment with prednisone (11.64±4.35%)(P<0.01), whereas RBCICR was of no difference between preand posttreatment. Our data suggested that difficiency of erythrocyte immunity function might have a link with pathogenesis of MG to some degree. The pathogenesis of MG involves humoral immunity disorder , as well as erythrocyte immunity compromise. Our data provided a new laboratory evidence for immunologic study of pathogenesis of MG, and a practical auxillary criteria for evaluation of immunotherapy.
出处
《卒中与神经疾病》
1997年第4期180-182,共3页
Stroke and Nervous Diseases
关键词
重症肌无力
红细胞
免疫功能
Myasthenia gravis Erythrocyte immunity function
