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地塞米松对罗哌卡因臂丛神经阻滞效果的影响 被引量:9

Effect of Dexamethasone Added to Ropivacaine on Axillary Brachial Plexus Block
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摘要 目的:评价地塞米松对罗哌卡因臂丛神经阻滞效果的影响。方法:45例择期或急症前臂及手部手术患者行腋路臂丛神经阻滞,ASAⅠ或Ⅱ级。随机分为3组,0.5%罗哌卡因30mL加地塞米松5mg(1mL),静脉注射生理盐水(NS)1mL(A组);0.5%罗哌卡因30mL加NS1mL,静脉注射地塞米松5mg(B组),0.5%罗哌卡因30mL加NS1mL,静脉注射NS1mL(C组)。结果:A组感觉、运动阻滞持续时间均长于B、C组(P<0.05),A组术后首次疼痛时间、镇痛持续时间明显长于B、C组(P<0.05),3组阻滞成功率为93%(14/15)、93%(14/15)和87%(13/15)。麻醉期间各组患者血流动力学均无明显改变。结论:地塞米松可以通过外周途径发挥镇痛作用,在0.5%罗哌卡因中加入5mg地塞米松可明显改善上肢手术臂丛神经阻滞效果,并可延长术后镇痛时间。 Objective: To study the effect of dexamethasone added to ropivacaine on axillary brachial plexus block. Methods:Forty-five patients scheduled for hand and forearm surgery under axillary brachial plexus black were randomly al-located to three groups. Patients in group A received 0.5% ropivacaine 30 mL and dexamethasone 1 mL (5 mg) with normal saline 1 mL intravenously. Patients in group B received 0.5% ropivacaine 30 mL and normal saline 1 mL with dexametha-sone 1 mL (5 mg) intravenously. Patients in group C received 0.5% ropivacaine 30 mL and normal saline 1 mL intravenously. Results: The onset times of sensory and motor block were similar among the three groups. The duration of sensory blockade[(13.2±2.0)h versus (7.8±2.1)h and (7.5±1.9)h] and motor blockade [(11.7±2.3)h versus (7.6±1.8)h and (7.3±2.2)h] were significantly longer in group A than those of groups B and C ( P 〈 0.05). Conclusion: Dexamethasone added to ropivacaine 0.5% solution prolonged axillary brachial plexus blockade in the duration of sensory and motor block.
出处 《天津医药》 CAS 北大核心 2008年第9期682-684,共3页 Tianjin Medical Journal
关键词 地塞米松 酰胺类 臂丛 神经传导阻滞 dexamethasone amides brachial plexus nerve block
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参考文献6

  • 1Movafegh A, Razazian M, Hajimaohamadi F, et al. Dexamethasone added to lidocaine prolongs axillary brachial plexus blockade [J]. Anesth Analg, 2006,102(1): 263-267.
  • 2徐凤莲,王亮.碳酸利多卡因、布比卡因联合地塞米松在臂丛阻滞中的应用[J].现代中西医结合杂志,2007,16(18):2575-2576. 被引量:3
  • 3Thomas S, Beevi S. Epidural dexamethasone reduces postoperative pain and analgesic requirements[J]. Can J Anesth, 2006,53(9): 899- 905.
  • 4Kopacz DJ, Lacouture PG, Wu D, et al. The dose response and effects of dexamethasone on bupivacaine microcapsules for intercostals blockade (T9 to T11) in healthy volunteers [J]. Anesth Analg, 2003,96(2): 576-582.
  • 5Bigat Z, Boztug N, Hadimioglu N, et al. Does examethasone improve the quality of intravenous regional anesthesia and analgesia? A randomized, controlled clinical study [J]. Anesth Analg, 2006,102(2): 605-609.
  • 6Holte K, Wemer MU, Lacouture PG, et al. Dexamethasone prolongs local analgesia after subcutaneous infiltration of bupivacaine microcapsules inhuman volunteers[J]. Anesthesiology, 2002,96(6): 1331 - 1335.

二级参考文献2

  • 1张元信 刘宝义 胡双贵.地塞米松对延长小儿臂丛阻滞时间及术后镇痛的疗效观察[J].中华医学杂志,1998,78:164-164.
  • 2盛卓人,孙俊科.临床实用麻醉学[M].3版.沈阳:辽宁科学技术出版社,1986:160

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