期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

GEM联合L-OHP 5-Fu治疗晚期胰腺癌47例疗效观察 被引量：3

暂未订购
导出
摘要 [目的]观察吉西他滨(GEM)联合奥沙利铂(L-OHP)治疗晚期胰腺癌的疗效。[方法]经手术或病理学证实为晚期胰腺癌患者87例,随机分成对照组用L-OHP5-氟脲嘧啶(5-Fu)3周方案治疗晚期胰腺癌患者40例,实验组用GEM联合L-OHP5-Fu治疗晚期胰腺癌47例,比较两组患者疾病相关临床症状改善、疗效和毒副反应情况。[结果]实验组部分缓解率(PR)为31.9%,半年及1年生存率分别为85.1%及25.5%,中位生存期为9.6个月,对照组PR为20%,半年生存率为62.5%,无1年生存者,中位生存期为7.4个月。实验组疼痛改善率为63.8%,对照组疼痛改善率为40%,两组比较差异有统计学意义(P﹤0.05)。两组均有不同程度的胃肠道及骨髓抑制等不良反应(P﹥0.05)。[结论]GEM联合L-OHP5-Fu治疗晚期胰腺癌患者能有效的改善患者的生存质量,延长患者生命,无严重毒副反应。
作者 董虹亮 陈明
机构地区 四川泸州医学院附属医院普外科
出处 《现代预防医学》 CAS 北大核心 2008年第19期3872-3873,共2页 Modern Preventive Medicine
关键词 吉西他滨 奥沙利铂 5-氟脲嘧啶 晚期胰腺癌 毒副反应
分类号 R735.9 [医药卫生—肿瘤]
  • 相关文献

参考文献13

  • 1张文俊,许国铭,李兆申.胰腺癌167例临床分析[J].第二军医大学学报,1998,19(5):497-498. 被引量：12
  • 2Cartwright TH, Cohn A, Vqrkey JA, et al. Phase Ⅱ study of oral capecitabice in patiens with advanced or metastaitc pancreatic cancer [J]. J Clin Oncd, 2002, 20: 160-164.
  • 3Huguier M, Barrier A, Valinas R, et al. Randomized trial of 5- Luorouraeil, leucovofin and cisplatin in advanced pancreatic cancer [J]. Hepatogastroenterology, 2001, 48: 875-878.
  • 4Wolff RA, Evans DB, Gravel DM, et al. Phase Ⅰ trial of gemcitabine combined with radiation for the treatment of Locally advanced pancreatic adenocarcinoma [J]. Clin Cancer Res, 2001, 7: 2246-2253.
  • 5Mehta VK, Poen JC, Ford JM, et al. Prtracted venous infusion 5- fluorouraal with concomitant radiotherapy compared with bolus 5- fluororaal for unresectable pancreatic cancer [J]. Am J Clin Oncol, 2001, 24: 155-159.
  • 6Fur use J, Maru Y, Yoshino M, et al. Hepatic arterial infusion of 5-fluorouracil for liver metastases from pancreatic carcinoma: results from a pilot study [J]. Hepatogastroenterololgy, 2001, 48: 208-211.
  • 7K lein B, sadi KOVE, Mishaeli M, et al. Comparison of 5-Fa and Leucovorin to gema tabine in the treatment of pancreatic cancer [J]. Onco Crep 2000, 7:875-873
  • 8Von Hoff DD, Goodwin AL, GqrciaL. AD vancas in the treatment of patients with pancreatic cancer: in provement in symptoms and survival time. The San Aantonio Drug Development Team[J]. Br J Cancer, 1998, 78 (Suppl3): 9-13.
  • 9Carmichael J, Fink u, Russell RC, et al. Phase Ⅱ study of gemcitabine in patients with advanced pancreatic cancer [J]. Br J cancer, 1996, 73: 101-105.
  • 10King RS, Gemcitabime, New first-line therapy for pancreatic cancer [J]. Cancer pract, 1996: 353-354.

二级参考文献2

  • 1黄筵庭，胃肠病学，1993年，1167页
  • 2刘昕曜，疾病临床诊断和疗效标准，1990年，121页

共引文献11

同被引文献22

  • 1王晓稼.抗肿瘤新药吉西他滨临床研究进展[J].肿瘤学杂志,2005,11(1):69-71. 被引量：26
  • 2Prost P, Ychou M, Azria D. Gemcitabine and pancreatic cancer[J]. Bull Cancer, 20112,89 Spec No :s9 1-s95.
  • 3Herrmann R, Bodoky G, Ruhstaller T, et al. Gemeitabine plus capecitabine compared with gemeitabine alone in advanced pancreatic cancer:a randomized, muhicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group[J].J Clin Oncol, 2007,25 (16) :2212-2217.
  • 4Heinemann V, Quietzsch D, Gieseler F, et al. Randomized phase Ill trial of gemeitabine plus cisplatin with gemeitabine alone in advanced pancreatic carcinoma [J]. J Clin Oneol,2006, 24(24): 3946-3952.
  • 5King RS. Gemcitabime. New first-line therapy for pancreatic cancer[J]. Cancer Pract, 1996,4(6) :353-354.
  • 6Duffaud F,Therasse P.New guidelines to evaluate the response to treatment in solid tumors[J].Bull Cancer,2000,87(12):881-886.
  • 7Miller AB,Hoogstraten B,Staquet M,et al.Reporting results of cancer treatment[J].Cancer,1981,47(1):207-214.
  • 8Maki RG,Wathen JK,Patel SR,et al.Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas:results of sarcoma alliance for research through collaboration study 002[J].J Glin Oncol,2007,25(19):2755-2763.
  • 9Merimaskv O,Meller L,Flusser G,et al.Gemcitabiue in soft tissue or bone sarcoma resistant to standard chemotherapy:a phase Ⅱ study[J].Cancer Chemotherpharmacol,2000,45(2):177-181.
  • 10Rauer S,Seeber S,Sehutte J.Gemeitahine in the treatment of soft tissue sarcomas[J].Onkologie,2004,27(2):180-186.

引证文献3

二级引证文献5

现代预防医学
2008年 第19期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部