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铁蛋白报告基因在磁共振分子影像学中的研究进展 被引量：6

Research progress of ferritin as a new MRI reporter gene in molecular imaging
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摘要 铁蛋白是体内铁储存的主要形式之一,它普遍存在于各种生物中。铁蛋白在细胞中的过度表达能够增加细胞对铁的摄取,促使细胞内、外铁重新分布,导致细胞内铁的净含量增加,磁共振成像时表现为横向弛豫率的增加,T2值的减低。近年来,铁蛋白作为一种新的内源性MRI报告基因逐渐引起人们的重视。现就铁蛋白作MRI报告基因的机制、研究现状及其发展前景做一概述。 Ferritin is a ubiquitously distributed protein in organisms. It is recognized as a storage pool of iron. Over expression of ferritin augments iron uptake and leads to redistribution of intracellular and extracellular iron. The alteration of MRI signals is caused by the increasing of intracellular iron. Several studies have shown that ferritin can decrease the value of T2 in MRI, and can be used as a novel endogenous MRI reporter gene.
作者 胡秋菊 王建东 卢光明
机构地区 南方医科大学临床医院南京军区总院 南京军区总院医学影像科
出处 《中国医学影像技术》 CSCD 北大核心 2008年第9期1480-1482,共3页 Chinese Journal of Medical Imaging Technology
基金 国家基础研究项目973资助(2006 CB705707)
关键词 铁蛋白 磁共振成像 报告基因 分子影像学 Ferritin Magnetic resonance imaging Report gene Molecular imaging
分类号 R445.2 [医药卫生—影像医学与核医学] R814.42 [医药卫生—影像医学与核医学]
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参考文献18

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二级参考文献22

  • 1[1]Dagmar Hogemann,Lee Josephson,Ralph Weissleder,et al.Improvement of MRI Probes To Allow Efficient Detection of Gene Expression.Bioconjugate Chem,2000,11:941-946
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  • 9[9]Gottesfeld Z,Neeman M.Ferritin effect on the transverse relaxation of water:NMR microscopy at 9.4 T.Magn Reson Med,1996,35(4):514-520.
  • 10[10]Cohen B,Dafni H,Meir G,et al.Ferritin as an endogenous MRI reporter for noninvasive imaging of gene expression in C6 glioma tumors.Neoplasia,2005,7(2):109-117.

共引文献3

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中国医学影像技术
2008年 第9期

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