摘要
近年来,利用基因治疗心血管疾病的实验与临床前期研究取得了较快的发展。分子影像学是在分子或细胞水平上研究活体生命或疾病过程的特定分子事件的新技术,为心血管疾病的基因治疗提供了一种实时、无创地检测方法,促进了这一治疗模式的发展和完善。本文主要综述分子影像学在心血管疾病基因治疗中的应用,包括分子探针、成像技术(包括核医学、MRI、超声、光学成像)的进展。
In recent years, experimental and preclinical studies for gene therapy of cardiovascular diseases achieved rapid developments. Molecular imaging is a novel discipline with the goal to display and quantify molecular and cellular targets in vivo, providing a real-time, non-invasive method to monitor gene therapy of cardiovascular diseases and promoting the development and perfection of this therapeutic mode. The application of molecular imaging in gene therapy of cardiovascular diseases including the advances of molecular probes and imaging technologies （nuclear medicine, MRI, ultrasound imaging and fluorescent） were reviewed in this article.
出处
《中国医学影像技术》
CSCD
北大核心
2009年第8期1512-1514,共3页
Chinese Journal of Medical Imaging Technology
基金
上海市教委重点学科建设基金(S30203)
关键词
分子影像学
心血管疾病
报告基因
Molecular imaging
Cardiovascular disease
Reporter gene
