摘要
目的探讨离心性环状红斑（EAC）的临床、组织病理、免疫病理变化及其之间的关系。方法临床收集病例，进行性别、年龄、病期、皮疹分布，皮疹形态，症状、伴发疾病等的分析，同时作皮疹的组织病理及直接免疫荧光检查。结果EAC最常见受累部位为下肢，常伴发多种疾病，以真菌病伴发较多见。病理组织学的基本特征为真皮上部或深部小血管周围的淋巴细胞致密浸润。直接免疫荧光检测的12份标本中，有6例标本的小血管壁显示有IgG、IgM、或C3的沉积。结论EAC是一种多因素诱发的疾病，皮疹的组织病理及直接免疫荧光检查提示在EAC的发病机制中，淋巴细胞的介导和循环性免疫复合物沉积于真皮小血管壁具有重要的作用。
Objective To investigate the clinical, histopathological and immunopathological characteristics of erythema annulare centrifugum （EAC）. Methods A retrospective study was performed on 54 cases of EAC collected from 2001 to 2005. Information was gathered about patients＇ sex, age, disease course, distribution and morphology of eruptions, symptoms, complications. Also, the findings of histopathology and direct immunofluorescence examination in some patients were evaluated. Results EAC most commonly occurred on the lower limb, and was usually complicated by various diseases among which mycosis predominated. Histological examination revealed compact lymphocyte infiltration in dermal vessels in 32 of these 54 patients. Direct immunofluorescence showed the deposition of IgG, IgM, or C3 on the walls of small vessels in 6 of 12 tissue samples tested. Conclusions EAC is a multifactorial disease, and it seems that the infiltration of lymphocytes and deposition of circulatory immune complex on small blood vessels in dermis may play important roles in its pathogenesis.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2008年第9期588-590,共3页
Chinese Journal of Dermatology
关键词
红斑
病理学
荧光抗体技术
直接
Erythema
Pathology
Fluorescent antibody technique, direct
