摘要
心律失常是临床上十分常见的疾病,心肌细胞膜离子通道的变化是其基本病理机制。近年来,甘松及其有效成分在抗心律失常作用方面的研究取得了许多进展。甘松抗心律失常主要机制在于其能阻止多种膜离子通道如钠通道(INa)、L-型钙通道(ICa-L)、延迟整流钾电流(IK)、瞬时外向钾电流(Ito)等,对这些通道的阻滞作用很可能通过改变动作电位时间从而发挥抗心律失常作用。
Arrhythmia is very common in clinic. Its basic pathologic mechanism is the change of myocardial membrane ion channels. In recent years, the researches on the anti-arrhythmic functions of nardostachys chinensis and its effective components have achieved a great progress. The main mechanism of its anti-arrhythmia functions is changing the action potential duration by blocking various membrane ion channels, including INa,ICa-L,IK and Ito.
出处
《现代诊断与治疗》
CAS
2008年第5期276-278,共3页
Modern Diagnosis and Treatment
关键词
甘松
离子通道
膜片钳
抗心律失常药物
Nardostachys chinensis
Ion channels
Patch clamp
Anti-arrhythmic drugs
