摘要
目的探讨氟西汀治疗抑郁症的临床疗效及安全性。方法将50例抑郁症患者随机分为A、B两组各25例,A组口服氟西汀治疗,B组口服丙咪嗪治疗。观察6 w。于治疗前及治疗2 w、4 w、6 w末采用汉密顿抑郁量表评定临床疗效,副反应量表评定不良反应。结果治疗6 w末,A组显效率88.0%、有效率96.0%;B组分别为84.0%、96.0%;两组总体疗效相当(P>0.05)。汉密顿抑郁量表评分,治疗2 w起两组均较治疗前有显著下降(P<0.01),且随着治疗时间的延续均呈持续性下降;同期两组间比较均无显著性差异(P>0.05)。A组改善睡眠障碍不明显,甚至出现失眠、激越等,抗胆碱能不良反应如口干、便秘、视物模糊、震颤、心动过速、ST-T改变等发生率显著低于B组(P<0.05)。结论氟西汀治疗抑郁症疗效与丙咪嗪相当,但不良反应发生率低、且程度较轻微、安全性高,依从性好。
Objective To explore curative effects and safety of fluoxetine in the treatment of depression. Methods 50 depression patients were randomly divided into group A（n=25） taking orally fluoxetine and group B（n=25） doing imipramine for 6 weeks. Efficacies were assessed with the Hamilton Depression Scale（HAMD） and adverse reactions with the Treatment Emergent Symptom Scale（TESS） before treatment and at the ends of the 2nd,4th and 6th week. Results At the end of the 6th week, excellence and effectiveness rates were 88.0% and 96.0% in group A and 84.0% and 96.0% in group B respectively; total efficacies of the 2 groups were equivalent（P）0.05）. Since the end of the 2nd week, the HAMD scores of both groups lowered more significantly compared with pre-treatment（P^0.01） and did continously along with treatment lasting; there were no significant differences in synchronization inter-group comparison（P〈0.05）. Improvements of sleep disorders were not obviuos,even developed insomnia, agitation and so on and incidences of such anticholinergic adverse raections as dry mouth, constipation, blurred vision, tremor, tachycardia and ST-T change were significantly lowere in the group ：＆ than in B（P〈0. 05）. Conclusion Flouxetine has therapeutic equivalence to imipramine, but incidence and level of its adverse reaction are lower and mild, and has higher safety and better compliance.
出处
《临床心身疾病杂志》
CAS
2008年第5期410-411,共2页
Journal of Clinical Psychosomatic Diseases
关键词
抑郁症
氟西汀
丙咪嗪
Depression
fluoxetine
imipramine
