摘要
目的比较文拉法辛与阿普唑仑治疗广泛性焦虑症的临床疗效及安全性。方法将87例广泛性焦虑患者随机分为两组,研究组43例,口服文拉法辛治疗,对照组44例,口服阿普唑仑治疗,观察6 w。于治疗前及治疗第1 w、2 w、4 w、6 w末采用汉密顿焦虑量表、临床总体印象量表评定临床疗效,副反应量表评定不良反应。结果治疗6 w末研究组有效率为88.4%,对照组为88.6%(P>0.05)。汉密顿焦虑量表、临床总体印象量表评分,两组随着治疗时间的延续均呈持续性下降,治疗1 w末对照组汉密顿焦虑量表评分较研究组下降显著(P<0.05),其它时点评分均无显著性差异。研究组不良反应发生率显著低于对照组(P<0.01),且程度较轻微,主要为头痛、恶心、失眠、便秘、头晕等。结论两组疗效相当,阿普唑仑较文拉法辛显效快,文拉法辛较阿普唑仑不良反应发生率低,且程度较轻。
Objective To compare the efficacy and safety of venlafaxine vs. alprazolam in the treatment of generalized anxiety disorder（GAD）. Methods 87 patients with GAD were randomly assigned to research group took orally venlafaxine（n=43） and control did alprazolam（n=44） for 6 weeks. The efficacies were assessed with the Hamilton Anxiety Scale（HAMA） and Clinical Global Impression（CGI） and adverse reactions with the Treatment Emergent Symptom Scale（TESS） before treatment and at the ends of the lst,2nd,4th and 6th week, respectively. Results At the end of the 6th week, effective rates were respectively 88.4% in the research and 88. 6% in the control （P〉0. 05）. Scores of the HAMA and the CGI lowered continously along with treatment lasting for both groups, the HAMA score did more significantly in the research than in the control at the end of the 1st week（P〈0.05） and there were no significant differences at other time-points. The rates of adverse reactions were significantly lower（P〈0.01） and levels milder in the research, and mainly headache, nausea, insomnia, constipation, dizzy and so on. Conclusion The both groups have therapeutic equivalence, alprazolam acts more rapidly than venlafaxine does, and the latter has fewer and milder adverse reactions.
出处
《临床心身疾病杂志》
CAS
2008年第5期400-401,共2页
Journal of Clinical Psychosomatic Diseases
关键词
广泛性焦虑症
文拉法辛
阿普唑仑
不良反应
Generalized anxiety disorder
venlafaxine
alprazolam
adverse reaction
