摘要
合成了（１Ｒ，２Ｓ）－１－二丁基氨基－１，２－二氢－２－茚醇及其对映体，首次将此类手性氨基醇用于苯乙酮的不对称还原反应研究，用温和的还原剂ＫＢＨ４，得到的还原产物１－苯基乙醇其最佳对映体过量值达８１％．同时还调查了反应时间对转化率和对映体过量值的影响，确定７０ｈ为最合适的反应时间。
R,2S) 1 Dibutylamino 2 indanol and its enantiomer were synthesized. These chiral amino alcohols were first applied to the asymmetric reduction of acetophenone. Using mild reductant KBH 4, optically active 1 phenylethanol was obtained with enantiomeric excesses up to 81%. The effect of reaction time on conversion and enantiomeric excesses was also investigated and 70 hours was found to be the most suitable reaction time.
关键词
不对称还原
手性氨基醇
苯乙酮
asymmetric reduction
chiral amino alcohol
acetophenone
potassium borohydride
