摘要
目的：探讨过氧化氢（H2O2）对EDHF介导的血管运动的影响。方法：采用器官槽法测定猪冠状动脉环张力，消炎痛及N-硝基-L-精氨酸水浴30min后，用前列腺素F2α预收缩血管，检测不同浓度（10^-10～10^-5moL／L）的乙酰胆碱诱导的EDHF介导的舒血管反应，并观察过氧化氢酶对其影响；去除内皮细胞，观察H：O：对血管活性的影响。结果：直接加入外源性H2O2可引起去除内皮后血管的剂量依赖性舒血管反应，过氧化氢酶可抑制乙酰胆碱引起的EDHF介导的舒血管反应。结论：H2O2可能具有类似EDHF的作用。
Objective：To study the effect of hydrogen dioxide on the EDHF-mediated relaxation. Method：The tone of porcine coronary tings were measured by organ chamber experiments. After 30 min incubated with N^ω-nitro-L-arginine and indomethaein, precontraeted with prostaglandin F2α, the EDHF - mediated relaxation induced by aeetyleholine （ 10^10～ 10^- 5 mol/L） applied was measured, and observe the effect of catalase on the EDHF EDHF-medlated relaxation induced by aeetyleholine. Vasoaetive properties of exogenous H2O2 were examined in endothelium -stripped porcine coronary rings. Result：Catalase markedly inhibited the EDHF-mediated relaxation induced by aeetyleholine, and exogenous H2O2 caused dose-dependently endothelium-independent relaxation. Conclusion： H2O2 may partially mimic the action of EDHF.
出处
《赣南医学院学报》
2008年第4期474-476,共3页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
江西省教育厅科技课题
赣教技字([2005]226号)
