摘要
伴随着高通量测序技术的快速发展和测序成本的降低,越来越多的微生物基因组全序列测定得以实现,从基因组学的层面了解乳酸菌的遗传结构和组成,进而分析和掌握其生物学功能已经逐渐成为可能。迄今为止已经有22株乳酸菌的基因组完成测序并公开发表,还有至少12株测序工作仍在进行中。本文在分析相关文献和生物信息数据基础上,从乳酸菌基因组特点、代谢多样性、进化及共线性四个方面对乳酸菌基因组学研究进展进行了总结,旨在为乳酸菌研究和应用提供参考。
With the advances and cost reducing of DNA-sequencing, genome determination for many microorganisms becomes available. For the research of lactic acid bacteria （LAB）, this progress will not only facilitate to understand their nature of hereditary constitution, but also gradually leads to the possibility for analysis and further control of their biological functions. At present, the whole genome for 22 strains of LAB have been completed and published, at least another 12 strains of LAB are under sequencing, Based on the published data, we described the research progression of LAB genomics from four aspects, including general features, diversity of metabolism, evolution and colinearity.
出处
《微生物学报》
CAS
CSCD
北大核心
2008年第9期1270-1275,共6页
Acta Microbiologica Sinica
基金
国家自然科学基金(30560097,30660135,30760156)
国家“863计划”(2006AA10Z345,2007AA10Z353)
教育部新世纪优秀人才支持计划资助(NCET-06-0269)~~
关键词
乳酸菌
基因组
代谢
进化
共线性
lactic acid bacteria （LAB）
genome
metabolism
evolution
colinearity
