摘要
动脉粥样硬化(As)不稳定斑块也称易损斑块.不稳定斑块表面溃疡形成、破裂及继发血栓形成,是引起急性心脑血管事件的主要病理基础。药物治疗对防治不稳定斑块破裂的发生,降低急性心脑血管事件的发病率具有重要意义。治疗不稳定斑块的药物主要有他汀、抗氧化剂等,其主要药理学机制是抗炎、抗氧化、调节细胞因子、抑制MMPs活性等作用。本文对不稳定斑块有治疗作用的药物研究与应用进展做一综述,为急性心脑血管事件的治疗提供理论依据及线索。
Unstable atherosclerosis（As）plaque is also called vulnerable plaque,were Ulcer,rupture or thrombosis were formed on the face of unstable plaque,which was the pathological base of acute cardiovascular and cerebral vessels events.It is of importance that drug treatment can prevent unstable plaque rupture and decrease the morbility of acute cardiovascular and cerebral vessels events. The main drugs for it are statins,antioxidant etc.Its mechanisms are antiinflammation,antioxidant,regulating cytokine,inhibiting matrix metalloprotease activity.In this article,research advances on treating vulnerable plaque have been reviewed to provide theoretical evidence for treating acute cardiovascular and cerebral vessels events.
出处
《现代生物医学进展》
CAS
2008年第8期1599-1602,共4页
Progress in Modern Biomedicine
基金
北京市科委重大项目资助(D0906006040191)
北京市优秀人才培养资助(20071D0300600084)
北京市中医局中西医结合重点学科资助。
