摘要
观察了创伤小鼠血清对淋巴细胞膜流动性的影响。结果显示，创伤小鼠血清对正常小鼠脾脏、胸腺、肠系膜淋巴结细胞及Ｔ细胞膜的流动性均有明显的抑制作用，但对Ｂ细胞膜的流动性无明显影响。创伤小鼠血清中丙二醛（ＭＤＡ）含量升高，超氧化物歧化酶（ＳＯＤ）活性及维生素Ｅ（ＶＥ）含量降低。ＶＥ和ＳＯＤ体内应用可明显逆转创伤小鼠血清中上述指标的变化，并明显缓解创伤血清对淋巴细胞膜流动性的抑制作用。表明创伤血清可降低淋巴细胞膜的流动性，且这一作用同创伤血清中的氧自由基有关。
Effect of posttrauma serum on lymphocytic membrane fluidity was studied. The results showed that serum from traumatized mice could significantly suppress membrane fluidity of lymphocytes from spleen, thymus, mesenteric lymph modes and of T cells in normal control, but had no effect on membrane fluidity of B cells. Malondialdehyde (MDA) contents in posttrauma serum increased while both superoxide dismutase(SOD)activity and vitamin E (VE) contents reduced. In vivo administration of VE or SOD could obviously reverse the changes of these parameters in posttrauma serum and atenuate the inhibition of serum from traumatized mice on lymphocytic membrane fluidity. It is suggested that posttrauma serum may depress lymphocytic membrane fluidity, and this effect is related to oxygen free radical.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1997年第6期410-412,共3页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金
关键词
创伤
淋巴细胞
膜流动性
wounds and injuries
lymphocytes
membrane fluidity
