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白细胞介素31与特应性皮炎

Interlukin 31 and atopic dermatitis
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摘要 IL-31是由Th2细胞分泌的一种新型细胞因子，它能结合由IL-31RA和制瘤素M受体（OSMR）组成的异二聚体型Ⅰ类细胞因子受体进行信号传导。IL-31及其受体mRNA水平的高低与不同的组织及刺激条件有关，其生物学活性与皮肤病理及炎性细胞募集有关，在特应性皮炎（AD）的发生和发展中发挥着重要的作用。 Interleukin 31 is a newly discovered cytokine produced by Th2 cells. It is involved in the signal transduction by combining to a heterodimeric type I cytokine receptor composed of IL-31 receptor A （IL-31 RA） and oncostatin M receptor （OSMR）. The levels of IL-31 and its receptors＇ mRNA are different in different tissue and conditions. Its biological activity is related to the skin physiology and inflammatory cell recruitment. It is play an importment role in the occurrence and development of atopic skin inflammation.
作者 夏小慧 郑慧芳 张腾国(审校)
机构地区 兰州城市学院 西北师范大学
出处 《国际免疫学杂志》 CAS 2008年第5期383-386,共4页 International Journal of Immunology
关键词 IL-31 受体 特应性皮炎 Interleukin 31 Receptor Atopic dermatitis
分类号 R758 [医药卫生—皮肤病学与性病学]
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参考文献16

  • 1Dillon SR, Sprecher C, Hammond A, et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nature Immunl, 2004,5 (7) :752-760.
  • 2Sonkoly E, Muller A, Eauerma AI, et al. IL-31 : a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol ,2006,117(2) : 411-417.
  • 3Diveu C, Eak-Hal AH, Froger J ,et al. Predominant expression of the long isoform of GP130-1ike (GPL) receptor is required for interleukin-31 signaling. Eur Cytokine Netw, 2004, 15 (4) :291- 302.
  • 4Chattopadhyay S, Tracy E, Liang P. Interleukin-31 and oneostatin-M mediate distinct signaling reactions and response pattems in lung epithelial cells. J Biol Chem ,2007,282 (5) :3014-3026.
  • 5Perrigoue JG, Li J, Zaph C, et al. IL-31-IL-31 R interactions negatively regulate type 2 inflammation in the lung. J Exp Med, 2007,204(3 ) :481-487.
  • 6Jawa RS, Chattopadhyay S, Tracy E, et al. Regulated Expression of the IL-31 Receptor in Bronchial and Alveolar Epithelial Cells, Pulmonary Fibroblasts, and Pulmonary Macrophages. J Interferon Cytokine Res, 2008,28 (4) : 207 -219.
  • 7Leung DY, Bieber T. Atopic dermatitis. Lancet , 2003,361 (9352) :151-160.
  • 8Takaoka A, Arai I, Sugimoto M, et al. Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis. Eur J Pharmacol, 2005,516(2) :180-181.
  • 9Morikawa Y, Tamura S, Minehata K,et al. Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia. J Neurosci, 2004,24(8) :1941-1947
  • 10Bando T, Morikawa Y, Komori T,et al. Complete overlap of interleukin-31 receptor A and oneostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns. Neuroseience, 2006,142 (4) : 1263-1271.
国际免疫学杂志
2008年 第5期

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